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Physician Awareness of Immune Responses to Polyethylene Glycol-Drug Conjugates.
- Source :
-
Clinical and translational science [Clin Transl Sci] 2018 Mar; Vol. 11 (2), pp. 162-165. Date of Electronic Publication: 2018 Jan 31. - Publication Year :
- 2018
-
Abstract
- Antibodies against polyethylene glycol (PEG) can critically jeopardize the efficacy and safety of PEGylated therapeutics. For some PEG-drugs, a sizeable fraction of patients develop anti-PEG antibodies (APA), leading to reduced efficacy and potential adverse events. We surveyed physicians from several specialties to assess their awareness of APA. Overall, 83% of the physicians surveyed indicated that they have recently prescribed PEGylated drugs. Although 91% of respondents were aware of antidrug antibodies in general, only 22% were aware of APA responses. Further, there was limited awareness (35%) of PEG's inclusion in prescribed PEGylated therapeutics. These findings bring to light a need for improved awareness of APA, potentially via targeted education of physicians who prescribe specific PEGylated therapeutics that could induce or are otherwise affected by APA. Finally, it will be critical to quantitate the extent of knowledge transfer from the research community to clinicians, especially on topics of patient safety.<br /> (© 2018 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.)
- Subjects :
- Antibodies immunology
Drug Compounding methods
Drug-Related Side Effects and Adverse Reactions etiology
Humans
Nanoconjugates adverse effects
Nanoconjugates chemistry
Polyethylene Glycols chemistry
Prescription Drugs chemistry
Surveys and Questionnaires statistics & numerical data
Clinical Competence statistics & numerical data
Drug-Related Side Effects and Adverse Reactions immunology
Physicians statistics & numerical data
Polyethylene Glycols adverse effects
Prescription Drugs adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1752-8062
- Volume :
- 11
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical and translational science
- Publication Type :
- Academic Journal
- Accession number :
- 29383836
- Full Text :
- https://doi.org/10.1111/cts.12537