Within-host dynamics and random duration of pathogen infection: Implications for between-host transmission.

Taking an ecological perspective, this paper reports theoretical and empirical results concerning fatal bacterial infections of adult insects. Two models, each combining deterministic and stochastic elements, characterize how the pathogen's dynamics might govern an infected host's mortality rate. We analyze the models in detail for exponential pathogen growth, and apply them to observed insect mortality when the pathogen's growth is unregulated. We then allow bacteriophage to generate fluctuations in the within-host pathogen density; we demonstrate that only one of our models matches host mortality rates when pathogen growth is regulated by phage. We generalize our results on mortality hazard of individual hosts to analyze how random duration of the infectious period can combine with probabilistic transmission events to affect between-host transmission.
(Copyright © 2018. Published by Elsevier Ltd.)