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Different concentrations and volumes of p-phenylenediamine in pet. (equivalent doses) are associated with similar patch test outcomes: a pilot study.
- Source :
-
Contact dermatitis [Contact Dermatitis] 2018 May; Vol. 78 (5), pp. 335-340. Date of Electronic Publication: 2018 Feb 02. - Publication Year :
- 2018
-
Abstract
- Background: Concern about causing active sensitization when patch testing is performed with p-phenylenediamine (PPD) 1% pet. has led to a recommendation to use PPD 0.3% pet. as a potentially safer preparation. However, the dose per area of allergen delivered, and hence the risk of active sensitization, depend on the amount dispensed into the patch test chamber, which can vary widely.<br />Objective: To evaluate whether patch testing with equivalent doses of different concentrations of PPD in pet. is associated with similar outcomes.<br />Methods: Seventeen known PPD-sensitive subjects were patch tested with different volumes and concentrations of PPD in pet. that deliver the same allergen dose per unit area (6 mg of PPD 1% pet. and 20 mg of PPD 0.3% pet. in Finn Chambers®, both equivalent to ∼ 0.09 mg/cm <superscript>2</superscript> ).<br />Results: Eleven patients (65%) had positive reactions to both doses; 4 patients (24%) had negative results [percentage agreement of 88% (15/17)]. One patient each had a positive reaction to only one dose.<br />Conclusions: The 88% concordance suggests that dose per unit area is more important in determining reactions to allergens than the excipient volume dispensed. Patch testing with a smaller volume of 1% PPD may be a reasonable alternative to testing with 20 mg of 0.3% PPD.<br /> (© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Allergens administration & dosage
Allergens adverse effects
Coloring Agents adverse effects
Dermatitis, Allergic Contact diagnostic imaging
Dose-Response Relationship, Immunologic
Female
Humans
Male
Middle Aged
Patch Tests adverse effects
Petrolatum
Phenylenediamines adverse effects
Pilot Projects
Prospective Studies
Coloring Agents administration & dosage
Patch Tests methods
Phenylenediamines administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0536
- Volume :
- 78
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Contact dermatitis
- Publication Type :
- Academic Journal
- Accession number :
- 29392743
- Full Text :
- https://doi.org/10.1111/cod.12951