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Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4.
- Source :
-
Immunity [Immunity] 2018 Feb 20; Vol. 48 (2), pp. 286-298.e6. Date of Electronic Publication: 2018 Jan 27. - Publication Year :
- 2018
-
Abstract
- Glucocorticoids are steroid hormones with strong anti-inflammatory and immunosuppressive effects that are produced in a diurnal fashion. Although glucocorticoids have the potential to induce interleukin-7 receptor (IL-7R) expression in T cells, whether they control T cell homeostasis and responses at physiological concentrations remains unclear. We found that glucocorticoid receptor signaling induces IL-7R expression in mouse T cells by binding to an enhancer of the IL-7Rα locus, with a peak at midnight and a trough at midday. This diurnal induction of IL-7R supported the survival of T cells and their redistribution between lymph nodes, spleen, and blood by controlling expression of the chemokine receptor CXCR4. In mice, T cell accumulation in the spleen at night enhanced immune responses against soluble antigens and systemic bacterial infection. Our results reveal the immunoenhancing role of glucocorticoids in adaptive immunity and provide insight into how immune function is regulated by the diurnal rhythm.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Cells, Cultured
Chemokine CXCL12 biosynthesis
Female
Immunologic Memory
Lymphocyte Activation
Male
Mice
Mice, Inbred C57BL
Receptors, Glucocorticoid physiology
Circadian Rhythm physiology
Glucocorticoids pharmacology
Receptors, CXCR4 physiology
Receptors, Interleukin-7 physiology
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4180
- Volume :
- 48
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Immunity
- Publication Type :
- Academic Journal
- Accession number :
- 29396162
- Full Text :
- https://doi.org/10.1016/j.immuni.2018.01.004