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Development of novel tasks for studying view-invariant object recognition in rodents: Sensitivity to scopolamine.
- Source :
-
Behavioural brain research [Behav Brain Res] 2018 May 15; Vol. 344, pp. 48-56. Date of Electronic Publication: 2018 Feb 02. - Publication Year :
- 2018
-
Abstract
- The capacity to recognize objects from different view-points or angles, referred to as view-invariance, is an essential process that humans engage in daily. Currently, the ability to investigate the neurobiological underpinnings of this phenomenon is limited, as few ethologically valid view-invariant object recognition tasks exist for rodents. Here, we report two complementary, novel view-invariant object recognition tasks in which rodents physically interact with three-dimensional objects. Prior to experimentation, rats and mice were given extensive experience with a set of 'pre-exposure' objects. In a variant of the spontaneous object recognition task, novelty preference for pre-exposed or new objects was assessed at various angles of rotation (45°, 90° or 180°); unlike control rodents, for whom the objects were novel, rats and mice tested with pre-exposed objects did not discriminate between rotated and un-rotated objects in the choice phase, indicating substantial view-invariant object recognition. Secondly, using automated operant touchscreen chambers, rats were tested on pre-exposed or novel objects in a pairwise discrimination task, where the rewarded stimulus (S+) was rotated (180°) once rats had reached acquisition criterion; rats tested with pre-exposed objects re-acquired the pairwise discrimination following S+ rotation more effectively than those tested with new objects. Systemic scopolamine impaired performance on both tasks, suggesting involvement of acetylcholine at muscarinic receptors in view-invariant object processing. These tasks present novel means of studying the behavioral and neural bases of view-invariant object recognition in rodents.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Automation, Laboratory
Cholinergic Antagonists pharmacology
Computers
Discrimination, Psychological drug effects
Dose-Response Relationship, Drug
Male
Mice, Inbred C57BL
Models, Animal
Muscarinic Antagonists pharmacology
Photic Stimulation
Rats, Long-Evans
Rotation
Pattern Recognition, Visual drug effects
Psychological Tests
Psychotropic Drugs pharmacology
Recognition, Psychology drug effects
Scopolamine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7549
- Volume :
- 344
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 29412155
- Full Text :
- https://doi.org/10.1016/j.bbr.2018.01.030