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Streptococcal Cysteine Protease-Mediated Cleavage of Desmogleins Is Involved in the Pathogenesis of Cutaneous Infection.
- Source :
-
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2018 Jan 24; Vol. 8, pp. 10. Date of Electronic Publication: 2018 Jan 24 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Streptococcus pyogenes is responsible for a wide variety of cutaneous infections ranging from superficial impetigo to fulminant invasive necrotizing fasciitis. Dysfunction of desmosomes is associated with the pathogenesis of cutaneous diseases. We identified streptococcal pyrogenic exotoxin B (SpeB) as a proteolytic factor that cleaves the extracellular domains of desmoglein 1 and 3. In an epicutaneous infection model, lesional skin infected with an speB deletion mutant were significantly smaller as compared to those caused by the wild-type strain. Furthermore, immunohistological analysis indicated cleavage of desmogleins that developed around the invasion site of the wild-type strain. In contrast, the speB mutant was preferentially found on the epidermis surface layer. Taken together, our findings provide evidence that SpeB-mediated degradation of desmosomes has a pathogenic role in development of S. pyogenes cutaneous infection.
- Subjects :
- Animals
Cysteine Proteases genetics
Disease Models, Animal
Humans
Mice
Mutation
Proteolysis
Streptococcus pyogenes genetics
Streptococcus pyogenes pathogenicity
Virulence
Cysteine Proteases metabolism
Desmogleins metabolism
Skin Diseases, Bacterial metabolism
Skin Diseases, Bacterial microbiology
Streptococcal Infections metabolism
Streptococcal Infections microbiology
Streptococcus pyogenes enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 2235-2988
- Volume :
- 8
- Database :
- MEDLINE
- Journal :
- Frontiers in cellular and infection microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 29416987
- Full Text :
- https://doi.org/10.3389/fcimb.2018.00010