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Effects of Bioreactor-Oxygenation During Extracorporeal Granulocytes Treatment in Septic Patients.
- Source :
-
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy [Ther Apher Dial] 2018 Aug; Vol. 22 (4), pp. 389-398. Date of Electronic Publication: 2018 Feb 08. - Publication Year :
- 2018
-
Abstract
- A granulocyte bioreactor for the extracorporeal treatment was developed to enhance the immune cell function in patients with severe sepsis. The influence of oxygenation on the used cells was tested in a prospective clinical study. Ten patients with severe sepsis were treated twice with the granulocyte bioreactor. The used cells were screened for functionality; values of blood gases, glucose and lactate were obtained from the recirculating bioreactor circuit. Five patients were treated with an oxygenator setup (Oxy group), five without oxygenator (Non-Oxy group). The overall in-hospital mortality was 50%. Significantly lower values of oxygen saturation, partial oxygen pressure, lactate, oxyburst and phagocytosis were seen in the Non-Oxy group compared with the Oxy group in the bioreactor circuit. Further studies with this approach are encouraged and should focus on the influence of oxygenation on production of reactive oxygen species and cytokines of used cells.<br /> (© 2018 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy.)
- Subjects :
- Adult
Aged
Blood Gas Analysis
Cytokines metabolism
Glucose metabolism
Hospital Mortality
Humans
Lactates metabolism
Male
Middle Aged
Oxygen metabolism
Prospective Studies
Reactive Oxygen Species metabolism
Sepsis immunology
Sepsis physiopathology
Bioreactors
Extracorporeal Circulation methods
Granulocytes metabolism
Sepsis therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1744-9987
- Volume :
- 22
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
- Publication Type :
- Academic Journal
- Accession number :
- 29418067
- Full Text :
- https://doi.org/10.1111/1744-9987.12657