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Effects of the Ketogenic diet in overweight divers breathing Enriched Air Nitrox.
- Source :
-
Scientific reports [Sci Rep] 2018 Feb 08; Vol. 8 (1), pp. 2655. Date of Electronic Publication: 2018 Feb 08. - Publication Year :
- 2018
-
Abstract
- Central Nervous System Oxygen Toxicity (CNS-OT) is one of the most harmful effects of Enriched Air Nitrox (EAN) diving. Protective factors of the Ketogenic Diet (KD) are antioxidant activity, the prevention of mitochondrial damage and anti-inflammatory mechanisms. We aimed to investigate if a short-term KD may reduce oxidative stress and inflammation during an hyperoxic dive. Samples from six overweight divers (mean ± SD, age: 55.2 ± 4.96 years; BMI: 26.7 ± 0.86 kg/m <superscript>2</superscript> ) were obtained a) before and after a dive breathing Enriched Air Nitrox and performing 20-minute mild underwater exercise, b) after a dive (same conditions) performed after 7 days of KD. We measured urinary 8-isoprostane and 8-OH-2-deoxyguanosine and plasmatic IL-1β, IL-6 and TNF-α levels. The KD was successful in causing weight loss (3.20 ± 1.31 Kgs, p < 0.01) and in limiting lipid peroxidation (3.63 ± 1.16 vs. 1.11 ± 0.22; p < 0.01) and inflammatory response (IL-1β = 105.7 ± 25.52 vs. 57.03 ± 16.32, p < 0.05; IL-6 = 28.91 ± 4.351 vs. 14.08 ± 1.74, p < 0.001; TNF-α = 78.01 ± 7.69 vs. 64.68 ± 14.56, p < 0.05). A short-term KD seems to be effective in weight loss, in decreasing inflammation and protective towards lipid peroxidation during hyperoxic diving.
- Subjects :
- Adult
Air
Decompression
Decompression Sickness drug therapy
Decompression Sickness urine
Deoxyguanosine urine
Dinoprost analogs & derivatives
Dinoprost urine
Exercise
Humans
Hyperoxia
Interleukin-1beta blood
Interleukin-6 analysis
Interleukin-6 blood
Male
Middle Aged
Nitrogen metabolism
Overweight metabolism
Oxidative Stress drug effects
Pilot Projects
Prospective Studies
Tumor Necrosis Factor-alpha blood
Decompression Sickness diet therapy
Diet, Ketogenic methods
Diving physiology
Nitrogen administration & dosage
Oxygen administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 29422679
- Full Text :
- https://doi.org/10.1038/s41598-018-20933-w