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Circulating Nesfatin-1 Levels and Type 2 Diabetes: A Systematic Review and Meta-Analysis.
- Source :
-
Journal of diabetes research [J Diabetes Res] 2017; Vol. 2017, pp. 7687098. Date of Electronic Publication: 2017 Dec 28. - Publication Year :
- 2017
-
Abstract
- The role of nesfatin-1 in glucose homeostasis has been investigated previously. However, although numerous studies have examined the relationships between circulating nesfatin-1 levels and type 2 diabetes, the conclusions are contradictory. We aimed to probe the relationship between circulating nesfatin-1 levels and type 2 diabetes by meta-analysis. Seven studies including 328 type 2 diabetes patients and 294 control subjects were included. Although there was no obvious difference in circulating nesfatin-1 levels between patients with type 2 diabetes and the control group (MD = -0.04; 95% CI = -0.32 to -0.23), subgroup analysis showed higher nesfatin-1 levels in newly diagnosed type 2 diabetes patients (MD = 0.59; 95% CI = 0.45 to 0.74) and significantly lower nesfatin-1 levels in type 2 diabetes patients receiving antidiabetic treatment (MD = -0.26; 95% CI = -0.33 to -0.20). In conclusion, the analysis supports a relationship between circulating nesfatin-1 levels and type 2 diabetes, where newly diagnosed type 2 diabetes was associated with an elevated Nesfatin-1 level, and type 2 diabetes patients receiving antidiabetic treatment showed lower circulating nesfatin-1 levels.
- Subjects :
- Biomarkers blood
Diabetes Mellitus, Type 2 drug therapy
Diabetes Mellitus, Type 2 physiopathology
Disease Progression
Down-Regulation drug effects
Humans
Hypoglycemic Agents therapeutic use
Nucleobindins
Reproducibility of Results
Calcium-Binding Proteins blood
DNA-Binding Proteins blood
Diabetes Mellitus, Type 2 blood
Nerve Tissue Proteins blood
Up-Regulation
Subjects
Details
- Language :
- English
- ISSN :
- 2314-6753
- Volume :
- 2017
- Database :
- MEDLINE
- Journal :
- Journal of diabetes research
- Publication Type :
- Academic Journal
- Accession number :
- 29445751
- Full Text :
- https://doi.org/10.1155/2017/7687098