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Engineering a Clinically Translatable Bioartificial Pancreas to Treat Type I Diabetes.
- Source :
-
Trends in biotechnology [Trends Biotechnol] 2018 Apr; Vol. 36 (4), pp. 445-456. Date of Electronic Publication: 2018 Feb 15. - Publication Year :
- 2018
-
Abstract
- Encapsulating, or immunoisolating, insulin-secreting cells within implantable, semipermeable membranes is an emerging treatment for type 1 diabetes. This approach can eliminate the need for immunosuppressive drug treatments to prevent transplant rejection and overcome the shortage of donor tissues by utilizing cells derived from allogeneic or xenogeneic sources. Encapsulation device designs are being optimized alongside the development of clinically viable, replenishable, insulin-producing stem cells, for the first time creating the possibility of widespread therapeutic use of this technology. Here, we highlight the status of the most advanced and widely explored implementations of cell encapsulation with an eye toward translating the potential of this technological approach to medical reality.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Clinical Trials as Topic
Humans
Insulin-Secreting Cells chemistry
Insulin-Secreting Cells transplantation
Materials Testing
Membranes, Artificial
Models, Animal
Bioartificial Organs
Diabetes Mellitus, Experimental therapy
Diabetes Mellitus, Type 1 therapy
Pancreas, Artificial
Tissue Engineering
Subjects
Details
- Language :
- English
- ISSN :
- 1879-3096
- Volume :
- 36
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Trends in biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 29455936
- Full Text :
- https://doi.org/10.1016/j.tibtech.2018.01.007