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FDG-PET/CT at the end of immuno-chemotherapy in follicular lymphoma: the prognostic role of the ratio between target lesion and liver SUV max (rPET).
- Source :
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Annals of nuclear medicine [Ann Nucl Med] 2018 Jun; Vol. 32 (5), pp. 372-377. Date of Electronic Publication: 2018 Feb 20. - Publication Year :
- 2018
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Abstract
- Aim: To retrospectively investigate the prognostic role of the ratio between target lesion and liver SUV <subscript>max</subscript> (rPET) in patients with follicular lymphoma (FL) submitted to FDG-PET/CT at the end of immuno-chemotherapy (PI-PET), and to compare rPET with International Harmonization Project criteria (IHP), Deauville Score (5p-DS) and FL International Prognostic Index at diagnosis (FLIPI).<br />Methods: Eighty-nine patients with FL undergoing PI-PET were evaluated. The receiver operating characteristic (ROC) approach was applied to identify the optimal cut-point of rPET with respect to 5-years progression free survival (PFS). The prognostic significance of rPET was compared with IHP, DS and FLIPI. Positive predictive value (PPV) and negative predictive value (NPV) were calculated using the presence of adverse events as gold standard.<br />Results: The ROC analysis for rPET as predictor of progression showed an optimal rPET cut-point of 0.98. Patients with positive values of IHP, DS and rPET had a PFS of 50, 30 and 31%. PPV were of 56, 80 and 80%, NPV of 83, 86 and 88%, respectively. DS and rPET differed only in two patients. FLIPI was not predictive of progression and relapse.<br />Conclusions: rPET is a prognostic factor in patients with FL submitted to PI-PET. Although it has a similar prognostic power as DS, it can have methodological advantages over visual analysis. PI-PET with different evaluation systems has a stronger prognostic power than FLIPI at diagnosis, so it could be useful to identify patients with FL at risk for early relapse after immuno-chemotherapy.
- Subjects :
- Antineoplastic Agents therapeutic use
Combined Modality Therapy
Disease-Free Survival
Female
Humans
Immunotherapy
Kaplan-Meier Estimate
Male
Middle Aged
Prognosis
ROC Curve
Retrospective Studies
Fluorodeoxyglucose F18
Liver diagnostic imaging
Lymphoma, Follicular diagnostic imaging
Positron Emission Tomography Computed Tomography
Radiopharmaceuticals
Subjects
Details
- Language :
- English
- ISSN :
- 1864-6433
- Volume :
- 32
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Annals of nuclear medicine
- Publication Type :
- Academic Journal
- Accession number :
- 29464479
- Full Text :
- https://doi.org/10.1007/s12149-018-1243-2