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Recent advances in the genomics and therapy of BCR/ABL1-positive and -negative chronic myeloproliferative neoplasms.
- Source :
-
Leukemia research [Leuk Res] 2018 Apr; Vol. 67, pp. 67-74. Date of Electronic Publication: 2018 Feb 14. - Publication Year :
- 2018
-
Abstract
- This review is based on the presentations and deliberations at the 7th John Goldman Chronic Myeloid Leukemia (CML) and Myeloproliferative Neoplasms (MPN) Colloquium which took place in Estoril, Portugal on the 15th October 2017, and the 11th post-ASH International Workshop on CML and MPN which took place on the 6th-7th December 2016, immediately after the 58th American Society of Hematology Annual Meeting. Rather than present a resume of the proceedings, we have elected to address some of the topical translational research and clinically relevant topics in greater detail. We address recent updates in the genetics and epigenetics of MPN, the mechanisms of transformation by mutant calreticulin, advances in the biology and therapy of systemic mastocytosis, clinical updates on JAK2 inhibitors and other therapeutic approaches for patients with MPNs, cardiovascular toxicity related to tyrosine kinase inhibitors and the concept of treatment-free remission for patients with CML.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antineoplastic Agents therapeutic use
Calreticulin genetics
Cardiovascular Diseases chemically induced
Cell Transformation, Neoplastic
Chronic Disease
Congresses as Topic
Epigenesis, Genetic
Humans
Janus Kinase 2 antagonists & inhibitors
Mastocytosis, Systemic drug therapy
Mutation
Myeloproliferative Disorders classification
Myeloproliferative Disorders diagnosis
Protein Kinase Inhibitors adverse effects
Remission Induction
Staurosporine analogs & derivatives
Staurosporine therapeutic use
Translational Research, Biomedical
Fusion Proteins, bcr-abl genetics
Myeloproliferative Disorders drug therapy
Myeloproliferative Disorders genetics
Protein Kinase Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5835
- Volume :
- 67
- Database :
- MEDLINE
- Journal :
- Leukemia research
- Publication Type :
- Academic Journal
- Accession number :
- 29466766
- Full Text :
- https://doi.org/10.1016/j.leukres.2018.02.008