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pH-dependent production of himeic acid A and its non-enzymatic conversions to himeic acids B and C.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2018 May 01; Vol. 26 (8), pp. 1869-1874. Date of Electronic Publication: 2018 Feb 20. - Publication Year :
- 2018
-
Abstract
- The fungus Aspergillus japonicus MF275 produces himeic acid A (1), containing a 4-pyrone ring, along with its congeners, himeic acids B (2) and C (3). During culture, 1 was gradually converted to 3, the corresponding 4-pyridone derivative. A study of the relationship between the culture pH and the fungal metabolites showed that a decrease from pH 6.5 to pH 2 is essential for production of 1, while a subsequent increase to pH 5 is necessary for production of 3. In addition, we revealed that 1 was non-enzymatically converted to 3 by the incorporation of an ammonium nitrogen atom in a pH 5 buffer, and that 1 was converted to 2 at a conversion ratio of 50% during incubation in MeOH for five days.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1464-3391
- Volume :
- 26
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 29486950
- Full Text :
- https://doi.org/10.1016/j.bmc.2018.02.034