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The inhibitory effect of Cordycepin on the proliferation of cisplatin-resistant A549 lung cancer cells.

Authors :
Cho SH
Kang IC
Source :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2018 Apr 06; Vol. 498 (3), pp. 431-436. Date of Electronic Publication: 2018 Feb 26.
Publication Year :
2018

Abstract

The goal of this study is to determine the anti-cancer mechanism of Cordycepin in A549 Cisplatin-Resistance (CR) lung cancer cells. Cordycepin inhibited the viability of A549CR cells in a dose-dependent manner. The cell inhibition was due to induction of apoptosis in the cells treated with Cordycepin by activation of caspase -3, -8 and -9 activities. The cell cycle analysis showed that accumulation of Sub G1 was observed in Cordycepin-treated with A549CR lung cancer cells. Based on the data of expression profile analysis of cell signaling proteins using IPS-FPAA, H-Ras was down-regulated in Cordycepin-treated A549CR cells. Collectively, anti-proliferative function of Cordycepin was due to stimulation of the cell apoptosis and the cell cycle arrest via caspases activation and down-regulation of H-Ras.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1090-2104
Volume :
498
Issue :
3
Database :
MEDLINE
Journal :
Biochemical and biophysical research communications
Publication Type :
Academic Journal
Accession number :
29496448
Full Text :
https://doi.org/10.1016/j.bbrc.2018.02.188