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[Impact of duration of untreated psychosis on quality of life and cognitive functions].
- Source :
-
L'Encephale [Encephale] 2019 Feb; Vol. 45 (1), pp. 22-26. Date of Electronic Publication: 2018 Feb 28. - Publication Year :
- 2019
-
Abstract
- Objectives: The duration of untreated psychosis is defined as the interval between the first psychotic symptoms and the first starting treatment. The duration of untreated psychosis is highly variable but often prolonged and may be influenced by several factors. Some studies suggested that duration of untreated psychosis is associated with poor outcome. The objectives of this study were to assess the duration of untreated psychosis in a Tunisian cohort and its impact on the quality of life and the cognitive functions of schizophrenic patients at 2 years.<br />Methods: We conducted a cross sectional study at Razi Hospital between January 2014 and June 2014 that included patients with Schizophrenia diagnosis as defined in the DSMIV-TR with regular monitoring for at least 2 years. Eligible participants are those who had been hospitalized for the first time, between January 2011 and December 2012 for a first psychotic episode. Data were collected from medical records and by interviewing the patients and their family. Duration of untreated psychosis was determined using the Symptom Onset in Schizophrenia Inventory. The quality of life was assessed by the 'Short Form-36 Health Survey' scale in its Arabic version. All patients were evaluated with 'The Tunisian Cognitive Battery' composed of 7 tests. Patient scores are expressed as 'Z scores', which represents the position of the scores in a term of standard deviation from the mean of healthy subjects established by the authors of the battery. We divided the population into two groups based on the duration of untreated psychosis median. A short duration of untreated psychosis was lower than the median, and a long duration of untreated psychosis was equal to or greater than the median.<br />Results: Our sample involved 42 patients with a mean age of 31.38 years. The average duration of untreated psychosis was 75.38 weeks with a range from 2 to 364 weeks and a median duration of 47.5 weeks. Patients with a short duration of untreated psychosis had a better quality of life with better scores for the majority of the dimensions and a significant difference in the limitations score due to the mental state (P=0.01). For cognitive function, the short duration of untreated psychosis was significantly correlated with a free recall of 'Hopkins Verbal Learning Test'.<br />Conclusion: Our study suggest that the average duration of untreated psychosis in Tunisia is comparable to the one reported in the literature and that a short duration of untreated psychosis is correlated with better outcomes in terms of quality of life and verbal learning.<br /> (Copyright © 2018 L'Encéphale, Paris. Published by Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Adult
Cohort Studies
Cross-Sectional Studies
Delayed Diagnosis
Diagnostic and Statistical Manual of Mental Disorders
Female
Humans
Male
Neuropsychological Tests
Prognosis
Psychotic Disorders therapy
Time-to-Treatment
Treatment Outcome
Tunisia
Verbal Learning
Young Adult
Cognition
Psychotic Disorders psychology
Quality of Life
Subjects
Details
- Language :
- French
- ISSN :
- 0013-7006
- Volume :
- 45
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- L'Encephale
- Publication Type :
- Academic Journal
- Accession number :
- 29499848
- Full Text :
- https://doi.org/10.1016/j.encep.2017.12.006