Back to Search
Start Over
Identification of Pseudomonas aeruginosa and airway bacterial colonization by an electronic nose in bronchiectasis.
- Source :
-
Respiratory medicine [Respir Med] 2018 Mar; Vol. 136, pp. 111-117. Date of Electronic Publication: 2018 Feb 13. - Publication Year :
- 2018
-
Abstract
- Rationale: Airway colonization by Potentially Pathogenic Microorganisms (PPM) in bronchiectasis is associated with worse clinical outcomes. The electronic nose is a non-invasive technology capable of distinguishing volatile organic compounds (VOC) in exhaled breath. We aim to explore if an electronic nose can reliably discriminate airway bacterial colonization in patients with bronchiectasis.<br />Methods: Seventy-three clinically stable bronchiectasis patients were included. PPM presence was determined using sputum culture. Exhaled breath was collected in Tedlar bags and VOC breath-prints were detected by the electronic nose Cyranose 320 <superscript>®</superscript> . Raw data was reduced to three factors with principal component analysis. Univariate ANOVA followed by post-hoc least significant difference test was performed with these factors. Patients were then classified using linear canonical discriminant analysis. Cross-validation accuracy values were defined by the percentage of correctly classified patients.<br />Results: Forty-one (56%) patients were colonized with PPM. Pseudomonas aeruginosa (n = 27, 66%) and Haemophilus influenzae (n = 7, 17%) were the most common PPM. VOC breath-prints from colonized and non-colonized patients were significantly different (accuracy of 72%, AUROC 0.75, p < 0.001). VOC breath-prints from Pseudomonas aeruginosa colonized patients were significantly different from those of patients colonized with other PPM (accuracy of 89%, AUROC 0.97, p < 0.001) and non-colonized patients (accuracy 73%, AUROC 0.83, p = 0.007).<br />Conclusions: An electronic nose can accurately identify VOC breath-prints of clinically stable bronchiectasis patients with airway bacterial colonization, especially in those with Pseudomonas aeruginosa.<br /> (Copyright © 2018. Published by Elsevier Ltd.)
- Subjects :
- Aged
Analysis of Variance
Bronchi microbiology
Bronchiectasis physiopathology
Cross-Sectional Studies
Female
Forced Expiratory Volume physiology
Humans
Male
Middle Aged
Pseudomonas Infections physiopathology
Vital Capacity physiology
Bronchiectasis microbiology
Electronic Nose
Pseudomonas Infections diagnosis
Pseudomonas aeruginosa isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1532-3064
- Volume :
- 136
- Database :
- MEDLINE
- Journal :
- Respiratory medicine
- Publication Type :
- Academic Journal
- Accession number :
- 29501241
- Full Text :
- https://doi.org/10.1016/j.rmed.2018.02.008