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Biomimetic Persistent Luminescent Nanoplatform for Autofluorescence-Free Metastasis Tracking and Chemophotodynamic Therapy.
- Source :
-
Analytical chemistry [Anal Chem] 2018 Mar 20; Vol. 90 (6), pp. 4188-4195. Date of Electronic Publication: 2018 Mar 09. - Publication Year :
- 2018
-
Abstract
- Metastasis is the main cause of death in people with cancer. Early diagnosis and targeted therapy for metastasis is crucial for the survival of the cancer patients. However, metastasis is hard to trace for its small size, dispersed distribution and unvascularized anatomy. Here we report a biomimetic persistent luminescent nanoplatform for noninvasive high-sensitive diagnosis and 808 nm laser controlled photodynamics assisted chemotherapy of metastasis. The nanoplatform is composed of a photosensitizer functionalized persistent luminescent nanoparticle core, a doxorubicin loaded hollow silica interlayer and a cancer cell membrane shell for effective metastasis theranostic. The cancer cell membrane shell prevents drug leakage and endows the nanoplatform with targeting ability to metastasis. The reactivatable persistent luminescence of persistent luminescent nanoparticles not only enables long-term in vivo metastasis tracking, but also provides internal light source for singlet oxygen generation to kill cancer cells and further break the membrane shell for drug release. This work provides a promising strategy to develop persistent luminescence imaging guided theranostic nanoplatforms for early metastasis.
- Subjects :
- Animals
Antibiotics, Antineoplastic therapeutic use
Cell Line, Tumor
Doxorubicin therapeutic use
Female
Mammary Neoplasms, Animal diagnostic imaging
Mammary Neoplasms, Animal pathology
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplasm Metastasis diagnostic imaging
Neoplasm Metastasis pathology
Optical Imaging methods
Photochemotherapy methods
Photosensitizing Agents therapeutic use
Theranostic Nanomedicine methods
Antibiotics, Antineoplastic administration & dosage
Doxorubicin administration & dosage
Luminescent Agents chemistry
Mammary Neoplasms, Animal drug therapy
Nanoparticles chemistry
Neoplasm Metastasis drug therapy
Photosensitizing Agents administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6882
- Volume :
- 90
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Analytical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 29504391
- Full Text :
- https://doi.org/10.1021/acs.analchem.8b00311