Effect of Antimicrobial Agents on Inflammatory Cytokines in Acute Leptospirosis.

Authors :: Fernando N
de Silva R
Handunnetti SM
Karunanayake L
De Silva NL
de Silva HJ
Rajapakse S
Premawansa S
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2018 Apr 26; Vol. 62 (5). Date of Electronic Publication: 2018 Apr 26 (Print Publication: 2018).
Publication Year :: 2018
Abstract: The aim of this study was to assess the inflammatory cytokine response and possible association with antimicrobial treatment with penicillin, ceftriaxone, and doxycycline in acute leptospirosis. In the early acute stage, interleukin-10 (IL-10) levels were higher in mild cases than in severe cases ( P = 0.01). IL-6 and IL-8 levels were low in patients who received >5 antimicrobial doses ( P < 0.01). IL-8 levels were negatively correlated with the number of ceftriaxone doses administered ( r = -0.315; P = 0.031). Further studies are needed to evaluate the possible downregulation of proinflammatory cytokines by ceftriaxone in leptospirosis.<br /> (Copyright © 2018 American Society for Microbiology.)

Subjects :: Anti-Infective Agents administration & dosage
Drug Administration Schedule
Female
Humans
Interleukin-10 blood
Interleukin-6 blood
Interleukin-8 blood
Male
Anti-Infective Agents therapeutic use
Cytokines blood
Leptospirosis blood
Leptospirosis drug therapy

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