Back to Search
Start Over
CCR4 Is Critically Involved in Skin Allergic Inflammation of BALB/c Mice.
- Source :
-
The Journal of investigative dermatology [J Invest Dermatol] 2018 Aug; Vol. 138 (8), pp. 1764-1773. Date of Electronic Publication: 2018 Mar 03. - Publication Year :
- 2018
-
Abstract
- Atopic dermatitis is a chronic inflammatory skin disease involving T-helper (Th) 2 cells, eosinophils, and mast cells. Although CCR4 is a major chemokine receptor expressed on Th2 cells and regarded as a potential therapeutic target for allergic diseases, its role in atopic dermatitis remains unclear. Here, by using a hydrogel patch as a transcutaneous delivery device for ovalbumin (an antigen) and Staphylococcus aureus δ-toxin (a mast cell activator), we efficiently induced acute atopic dermatitis-like skin lesions in BALB/c mice, a strain prone to Th2 responses, which were characterized by increased numbers of eosinophils, mast cells, and CCR4-expressing Th2 cells in the skin lesions; elevated levels of total and ovalbumin-specific IgE in the sera; and increased expression of IL-4, IL-17A, IL-22, CCL17, CCL22, and CCR4 in the skin lesions. Of note, the same model was less efficient in C57BL/6 mice, a strain prone to Th1 responses. Using this atopic dermatitis model in BALB/c mice, we demonstrated that CCR4-deficiency or a CCR4 antagonist ameliorated the allergic responses. Collectively, these results demonstrate that CCR4 plays a pivotal role in skin allergic inflammation of BALB/c mice by recruiting CCR4-expressing Th2 cells and Th17 cells.<br /> (Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Bacterial Toxins administration & dosage
Bacterial Toxins immunology
Dermatitis, Atopic pathology
Disease Models, Animal
Eosinophils immunology
Humans
Mast Cells immunology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Ovalbumin administration & dosage
Ovalbumin immunology
Receptors, CCR4 antagonists & inhibitors
Receptors, CCR4 genetics
Receptors, CCR4 metabolism
Skin cytology
Skin immunology
Skin pathology
Th17 Cells metabolism
Th2 Cells metabolism
Dermatitis, Atopic immunology
Receptors, CCR4 immunology
Th17 Cells immunology
Th2 Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1523-1747
- Volume :
- 138
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of investigative dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 29510192
- Full Text :
- https://doi.org/10.1016/j.jid.2018.02.027