Back to Search
Start Over
Enzyme Degradable Hyperbranched Polyphosphoester Micellar Nanomedicines for NIR Imaging-Guided Chemo-Photothermal Therapy of Drug-Resistant Cancers.
- Source :
-
Biomacromolecules [Biomacromolecules] 2018 Apr 09; Vol. 19 (4), pp. 1130-1141. Date of Electronic Publication: 2018 Mar 13. - Publication Year :
- 2018
-
Abstract
- Multidrug resistance (MDR) is the major cause for chemotherapy failure, which constitutes a formidable challenge in the field of cancer therapy. The synergistic chemo-photothermal treatment has been reported to be a potential strategy to overcome MDR. In this work, rationally designed enzyme-degradable, hyperbranched polyphosphoester nanomedicines were developed for reversing MDR via the codelivery of doxorubicin and IR-780 (hPPE <subscript>DOX&IR</subscript> ) as combined chemo-photothermal therapy. The amphiphilic hyperbranched polyphosphoesters with phosphate bond as the branching point were synthesized via a simple but robust one-step polycondensation reaction. The self-assembled hPPE <subscript>DOX&IR</subscript> exhibited good serum stability, sustained release, preferable tumor accumulation, and enhanced drug influx of doxorubicin in resistant MCF-7/ADR cells. Moreover, the degradation of hPPE <subscript>DOX&IR</subscript> was accelerated in the presence of alkaline phosphatase, which was overexpressed in various cancers, resulting in the fast release of encapsulated doxorubicin. The enzyme-degradable polymer generated synergistic chemo-photothermal cytotoxicity against MCF-7/ADR cells and, thus, the efficient ablation of DOX-resistant tumor without regrowth. This delivery system may open a new avenue for codelivery of chemo- and photothermal therapeutics for MDR tumor therapy.
- Subjects :
- Combined Modality Therapy
Doxorubicin chemistry
Doxorubicin pharmacology
Drug Resistance, Multiple drug effects
Drug Therapy methods
Humans
Indoles chemistry
Indoles pharmacology
MCF-7 Cells
Phototherapy
Drug Delivery Systems
Drug Resistance, Neoplasm drug effects
Nanomedicine
Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1526-4602
- Volume :
- 19
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biomacromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 29514006
- Full Text :
- https://doi.org/10.1021/acs.biomac.7b01793