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Role of Human Leukocyte Antigens (HLA) in Autoimmune Diseases.

Role of Human Leukocyte Antigens (HLA) in Autoimmune Diseases.

Authors :
Bodis G
Toth V
Schwarting A
Source :
Rheumatology and therapy [Rheumatol Ther] 2018 Jun; Vol. 5 (1), pp. 5-20. Date of Electronic Publication: 2018 Mar 07.
Publication Year :
2018

Abstract

Since the discovery of HLA 60 years ago, it has contributed to the understanding of the immune system as well as of the pathogenesis of several diseases. Aside from its essential role in determining donor-recipient immune compatibility in organ transplantation, HLA genotyping is meanwhile performed routinely as part of the diagnostic work-up of certain autoimmune diseases. Considering the ability of HLA to influence thymic selection as well as peripheral anergy of T cells, its role in the pathogenesis of autoimmunity is understandable. The aim of this paper is to provide a brief overview of the role and current clinical relevance of HLA-B27 in spondyloarthritis and HLA-B51 in Behçet's disease as well as HLA-DQ2/DQ8 in celiac disease and HLA-DRB1 in rheumatoid arthritis and to discuss possible future implications.

Details

Language :
English
ISSN :
2198-6576
Volume :
5
Issue :
1
Database :
MEDLINE
Journal :
Rheumatology and therapy
Publication Type :
Academic Journal
Accession number :
29516402
Full Text :
https://doi.org/10.1007/s40744-018-0100-z