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Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal.

Authors :
Isidro J
Santos A
Nunes A
Borges V
Silva C
Vieira L
Mendes AL
Serrano M
Henriques AO
Gomes JP
Oleastro M
Source :
Emerging infectious diseases [Emerg Infect Dis] 2018 Apr; Vol. 24 (4), pp. 741-745.
Publication Year :
2018

Abstract

We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.

Subjects

Subjects :
Amino Acid Sequence
Clostridioides difficile classification
Genome, Bacterial
Humans
Microbial Sensitivity Tests
Mutation
Phylogeny
Portugal epidemiology
Whole Genome Sequencing
Anti-Bacterial Agents pharmacology
Clostridioides difficile drug effects
Clostridioides difficile genetics
Drug Resistance, Bacterial
Enterocolitis, Pseudomembranous epidemiology
Enterocolitis, Pseudomembranous microbiology
Imipenem pharmacology
Ribotyping

Details

Language :
English
ISSN :
1080-6059
Volume :
24
Issue :
4
Database :
MEDLINE
Journal :
Emerging infectious diseases
Publication Type :
Academic Journal
Accession number :
29553322
Full Text :
https://doi.org/10.3201/eid2404.170095
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