Back to Search
Start Over
Association of serum biomarkers with outcomes of cardiac arrest patients undergoing ECMO.
- Source :
-
The American journal of emergency medicine [Am J Emerg Med] 2018 Nov; Vol. 36 (11), pp. 2020-2028. Date of Electronic Publication: 2018 Mar 10. - Publication Year :
- 2018
-
Abstract
- Background: Recently, a series of studies have been conducted to investigate the association of the common biochemical biomarkers, such as serum lactate and creatinine, with clinical outcomes in cardiac arrest patients treated with extracorporeal membrane oxygenation (ECMO), however, the results were not consistent and the sample size of primary studies is limited. In the present study, we performed a systematic review and meta-analysis to summarize the associations.<br />Methods: Relevant studies in English databases (PubMed, ISI web of science, and Embase) and Chinese databases (Wanfang and CNKI) up to January 2018 were systematically searched. Crude ORs or HRs from the included studies were extracted and pooled to summarize the associations of lactate and creatinine with clinical outcomes including survival and neurological outcomes in ECMO treated cardiac arrest patients.<br />Results: 17 papers containing 903 cases were included in the present meta-analysis study. After pooling all the eligible studies, we identified the significant associations of high lactate level with poor survival (N=13, OR=1.335, 95%CI=1.167-1.527, P<0.001) and poor neurological outcome (N=2, HR=1.058, 95%CI=1.020-1.098, P=0.002) in CA patients treated with ECMO and a slight significant association of high creatinine with poor survival was also found (N=7, OR=1.010, 95%CI=1.002-1.018, P=0.015).<br />Conclusions: High serum lactate level was associated with poor survival and poor neurological outcome in CA patients treated with ECMO. Further well-designed studies with larger sample size should be conducted to confirm the results.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Child
Child, Preschool
Creatinine metabolism
Female
Heart Arrest blood
Hemoglobins metabolism
Humans
Infant
Infant, Newborn
Lactic Acid metabolism
Male
Middle Aged
Prospective Studies
Retrospective Studies
Treatment Outcome
Young Adult
Biomarkers metabolism
Extracorporeal Membrane Oxygenation
Heart Arrest therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8171
- Volume :
- 36
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The American journal of emergency medicine
- Publication Type :
- Academic Journal
- Accession number :
- 29559353
- Full Text :
- https://doi.org/10.1016/j.ajem.2018.03.015