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Diminished CD40L expression on T-cells in a case of disseminated cryptococcosis.
- Source :
-
Indian journal of pathology & microbiology [Indian J Pathol Microbiol] 2018 Jan-Mar; Vol. 61 (1), pp. 137-140. - Publication Year :
- 2018
-
Abstract
- X-linked hyperimmunoglobulin M (HIGM) syndrome may increase the susceptibility of patients to disseminated cryptococcal infections primarily due to CD40L deficiency that causes defective cross talk between T- and B-cells, thus preventing class switching. In HIGM syndrome, serum IgM levels are elevated with severe reduction in serum immunoglobulin G (IgG) and IgA levels. In addition, the expression of CD40L (CD154) on in vitro-activated T-cells is severely reduced or absent. Here, we describe a rare, and perhaps, the first reported case in India of a 3-year-old male child with X-linked HIGM immunodeficiency syndrome who developed disseminated Cryptococcosis. Evaluation of the serum IgG profile of the patient revealed increased serum IgM levels with reduced IgG and IgA levels. Both the frequency and the function of T-cells, primarily CD40L on activated T-cells, showed weak expression suggestive of HIGM syndrome.<br />Competing Interests: There are no conflicts of interest
- Subjects :
- B-Lymphocytes immunology
CD40 Ligand immunology
Child, Preschool
Cryptococcosis diagnosis
Cryptococcosis epidemiology
Humans
Immunoglobulin G blood
Immunoglobulin M blood
Immunologic Deficiency Syndromes congenital
India epidemiology
Male
Mutation
CD40 Ligand genetics
Cryptococcosis blood
Cryptococcosis immunology
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0974-5130
- Volume :
- 61
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Indian journal of pathology & microbiology
- Publication Type :
- Report
- Accession number :
- 29567905
- Full Text :
- https://doi.org/10.4103/IJPM.IJPM_761_16