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Oxidative stress as a possible mechanism of statin-induced myopathy.
- Source :
-
Inflammopharmacology [Inflammopharmacology] 2018 Jun; Vol. 26 (3), pp. 667-674. Date of Electronic Publication: 2018 Mar 24. - Publication Year :
- 2018
-
Abstract
- Statins, inhibitors of hydroxy methyl glutaryl coenzyme-A (HMG-CoA) reductase, are the most widely used drugs for treating hypercholesterolemia. However, statins can cause disabling myopathy as their main adverse effect. Several molecular mechanisms underlie the statin-induced myopathy including the decrease in the levels of essential mevalonate and cholesterol derivatives. This review discusses a further mechanism involving the loss of other anti-oxidant defenses besides ubiquinone (Co-Q) in skeletal muscles which produce a significant amount of reactive oxygen species (ROS). Therefore, to maintain their function, skeletal muscles need a high level of anti-oxidants.
- Subjects :
- Animals
Cholesterol metabolism
Humans
Muscle, Skeletal drug effects
Muscle, Skeletal metabolism
Muscle, Skeletal pathology
Muscular Diseases diagnosis
Oxidative Stress physiology
Reactive Oxygen Species metabolism
Risk Factors
Hydroxymethylglutaryl-CoA Reductase Inhibitors adverse effects
Muscular Diseases chemically induced
Muscular Diseases metabolism
Oxidative Stress drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1568-5608
- Volume :
- 26
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Inflammopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 29574631
- Full Text :
- https://doi.org/10.1007/s10787-018-0469-x