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Serologic markers of viral infection and risk of non-Hodgkin lymphoma: A pooled study of three prospective cohorts in China and Singapore.
- Source :
-
International journal of cancer [Int J Cancer] 2018 Aug 01; Vol. 143 (3), pp. 570-579. Date of Electronic Publication: 2018 Apr 06. - Publication Year :
- 2018
-
Abstract
- Incidence rates of non-Hodgkin lymphoma (NHL) and distributions of certain viruses differ between East Asian and Western populations. There are limited data on associations between serologic markers of multiple viral infections in pre-diagnostic blood and NHL risk in East Asians. We conducted a nested case-control study of 214 NHL cases and 214 matched controls from three population-based prospective cohorts in Shanghai and Singapore. Antibodies against antigens from herpesviruses, Hepatitis B (HBV) and C (HCV) virus and polyomaviruses were measured in plasma or serum using fluorescent bead-based multiplex assays. Conditional logistic regression was used to evaluate associations between antibody levels and NHL risk. An increased risk of NHL was observed for higher compared to lower EA-D (Odds Ratio (OR) = 2.04, 95% Confidence Interval (CI) = 1.10-3.81; p <subscript>trend</subscript> = 0.005) and ZEBRA (OR = 2.17, 95% CI = 0.96-4.89; p <subscript>trend</subscript> = 0.008) Epstein-Barr Virus (EBV) antibodies, as well as for antibody seropositivity against the IE1A human herpesvirus-6 (HHV-6) antigen (OR = 1.85, 95% CI = 1.04-3.29). An increased NHL risk was also observed for higher compared to lower antibodies against the HBV-HBc and HBe antigens. An increased risk of NHL in relation to EBV and HBV infection in East Asians is consistent with findings in several studies of Western populations, suggesting similar viral risk factors for NHL in these diverse populations with distinct patterns of NHL. The association between HHV-6 antibodies and NHL has not previously been reported in a prospective study in this population and will require replication.<br /> (© 2018 UICC.)
- Subjects :
- Aged
Case-Control Studies
China epidemiology
Female
Humans
Lymphoma, Non-Hodgkin epidemiology
Male
Middle Aged
Odds Ratio
Population Surveillance
Risk Assessment
Risk Factors
Singapore epidemiology
Virus Diseases virology
Biomarkers blood
Lymphoma, Non-Hodgkin blood
Lymphoma, Non-Hodgkin etiology
Virus Diseases complications
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0215
- Volume :
- 143
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 29574937
- Full Text :
- https://doi.org/10.1002/ijc.31385