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VEGF and VEGFB Play Balancing Roles in Adipose Differentiation, Gene Expression, and Function.
- Source :
-
Endocrinology [Endocrinology] 2018 May 01; Vol. 159 (5), pp. 2036-2049. - Publication Year :
- 2018
-
Abstract
- Obesity is the result of abnormal adipose development and energy metabolism. Using vascular endothelial growth factor (VEGF) B-knockout and inducible VEGF downregulation mouse models, we have shown that VEGFB inactivation caused expansion of white adipose, whitening of brown adipose, an increase in fat accumulation, and a reduction in energy consumption. At the same time, expression of the white adipose-associated genes was increased and brown adipose-associated genes decreased. VEGF repression, in contrast, induced brown adipose expansion and brown adipocyte development in white adipose, increased energy expenditure, upregulated brown adipose-associated genes, and downregulated white adipose-associated genes. When VEGFB-knockout and VEGF-repressed mice are crossed together, VEGF and VEGFB can counteractively regulate large numbers of genes and efficiently reverse each other's roles. These genes, under counteractive VEGF and VEGFB regulations, include transcription factors, adhesion molecules, and metabolic enzymes. This balancing role is confirmed by morphologic and functional changes. This study reports that VEGF and VEGFB counteractively regulate adipose development and function in energy metabolism.
- Subjects :
- Adipocytes, Brown metabolism
Adipocytes, White metabolism
Adipose Tissue metabolism
Animals
Down-Regulation
Gene Expression Regulation
Mice
Mice, Knockout
Obesity genetics
Obesity metabolism
Adipogenesis genetics
Adipose Tissue, Brown metabolism
Adipose Tissue, White metabolism
Energy Metabolism genetics
Vascular Endothelial Growth Factor A genetics
Vascular Endothelial Growth Factor B genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1945-7170
- Volume :
- 159
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 29596616
- Full Text :
- https://doi.org/10.1210/en.2017-03246