Back to Search
Start Over
Bioelectrical Impedance Analysis-Derived Measurements in Chronic Hepatitis C: Clinical Relevance of Fat-Free Mass and Phase Angle Evaluation.
- Source :
-
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition [Nutr Clin Pract] 2018 Apr; Vol. 33 (2), pp. 238-246. Date of Electronic Publication: 2017 Dec 18. - Publication Year :
- 2018
-
Abstract
- Objective: Because cirrhotic patients are at high risk of malnutrition and sarcopenia, we evaluated the prevalence of low fat-free mass index (FFMI) and low phase angle (PhA) among patients with chronic hepatitis C (CHC).<br />Methods: In total, 135 subjects with CHC (50.4% males; mean age, 52.4 ± 11.8 years; 65.9% noncirrhotic and 34.1% compensated cirrhotic patients) were prospectively included and evaluated by bioelectrical impedance analysis. Subjective global assessment was used to evaluate malnutrition.<br />Results: Low FFMI and low PhA were identified in 21.5% and 23.7% of the patients, respectively. Compensated cirrhotic patients had lower PhA values than those without cirrhosis. Low FFMI was associated with male sex (odds ratio [OR], 2.74; 95% confidence interval [CI], 1.00-7.01; P = .04) and malnutrition (OR, 4.27; 95% CI, 1.42-12.90; P = .01). Low PhA was associated with cirrhosis (OR, 3.92; 95% CI, 1.56-9.86; P = .004), malnutrition (OR, 5.52; 95% CI, 1.73-17.62; P = .004), and current alcohol use (OR, 2.77; 95% CI, 1.01-7.58; P = .05). Reactance (Xc) normalized for height (H), an indicator of muscle strength, was independently associated with male sex, age, hypertension, and serum albumin.<br />Conclusion: Host factors, including clinical comorbidities, lifestyle, and nutrition status, are associated with low FFMI and low PhA in noncirrhotic and in compensated cirrhotic patients with CHC. These findings highlight the relevance of evaluating body composition in patients chronically infected by hepatitis C virus independently of the stage of liver disease.<br /> (© 2017 American Society for Parenteral and Enteral Nutrition.)
- Subjects :
- Adult
Body Composition
Brazil epidemiology
Comorbidity
Cross-Sectional Studies
Electric Impedance
Female
Hepatitis C, Chronic epidemiology
Hospitals, University
Humans
Liver Cirrhosis epidemiology
Liver Cirrhosis etiology
Liver Cirrhosis, Alcoholic epidemiology
Male
Malnutrition epidemiology
Malnutrition etiology
Middle Aged
Outpatient Clinics, Hospital
Prevalence
Prospective Studies
Risk
Sarcopenia epidemiology
Sarcopenia etiology
Sex Factors
Hepatitis C, Chronic physiopathology
Malnutrition diagnosis
Nutrition Assessment
Sarcopenia diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1941-2452
- Volume :
- 33
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 29596718
- Full Text :
- https://doi.org/10.1177/0884533617728487