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Bioelectrical Impedance Analysis-Derived Measurements in Chronic Hepatitis C: Clinical Relevance of Fat-Free Mass and Phase Angle Evaluation.

Authors :
Bering T
Diniz KGD
Coelho MPP
de Souza ACM
de Melo LF
Vieira DA
Soares MMS
Kakehasi AM
Correia MITD
Teixeira R
Queiroz DMM
Rocha GA
Silva LD
Source :
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition [Nutr Clin Pract] 2018 Apr; Vol. 33 (2), pp. 238-246. Date of Electronic Publication: 2017 Dec 18.
Publication Year :
2018

Abstract

Objective: Because cirrhotic patients are at high risk of malnutrition and sarcopenia, we evaluated the prevalence of low fat-free mass index (FFMI) and low phase angle (PhA) among patients with chronic hepatitis C (CHC).<br />Methods: In total, 135 subjects with CHC (50.4% males; mean age, 52.4 ± 11.8 years; 65.9% noncirrhotic and 34.1% compensated cirrhotic patients) were prospectively included and evaluated by bioelectrical impedance analysis. Subjective global assessment was used to evaluate malnutrition.<br />Results: Low FFMI and low PhA were identified in 21.5% and 23.7% of the patients, respectively. Compensated cirrhotic patients had lower PhA values than those without cirrhosis. Low FFMI was associated with male sex (odds ratio [OR], 2.74; 95% confidence interval [CI], 1.00-7.01; P = .04) and malnutrition (OR, 4.27; 95% CI, 1.42-12.90; P = .01). Low PhA was associated with cirrhosis (OR, 3.92; 95% CI, 1.56-9.86; P = .004), malnutrition (OR, 5.52; 95% CI, 1.73-17.62; P = .004), and current alcohol use (OR, 2.77; 95% CI, 1.01-7.58; P = .05). Reactance (Xc) normalized for height (H), an indicator of muscle strength, was independently associated with male sex, age, hypertension, and serum albumin.<br />Conclusion: Host factors, including clinical comorbidities, lifestyle, and nutrition status, are associated with low FFMI and low PhA in noncirrhotic and in compensated cirrhotic patients with CHC. These findings highlight the relevance of evaluating body composition in patients chronically infected by hepatitis C virus independently of the stage of liver disease.<br /> (© 2017 American Society for Parenteral and Enteral Nutrition.)

Details

Language :
English
ISSN :
1941-2452
Volume :
33
Issue :
2
Database :
MEDLINE
Journal :
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
Publication Type :
Academic Journal
Accession number :
29596718
Full Text :
https://doi.org/10.1177/0884533617728487