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Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.

Authors :
Mattsson N
Groot C
Jansen WJ
Landau SM
Villemagne VL
Engelborghs S
Mintun MM
Lleo A
Molinuevo JL
Jagust WJ
Frisoni GB
Ivanoiu A
Chételat G
Resende de Oliveira C
Rodrigue KM
Kornhuber J
Wallin A
Klimkowicz-Mrowiec A
Kandimalla R
Popp J
Aalten PP
Aarsland D
Alcolea D
Almdahl IS
Baldeiras I
van Buchem MA
Cavedo E
Chen K
Cohen AD
Förster S
Fortea J
Frederiksen KS
Freund-Levi Y
Gill KD
Gkatzima O
Grimmer T
Hampel H
Herukka SK
Johannsen P
van Laere K
de Leon MJ
Maier W
Marcusson J
Meulenbroek O
Møllergård HM
Morris JC
Mroczko B
Nordlund A
Prabhakar S
Peters O
Rami L
Rodríguez-Rodríguez E
Roe CM
Rüther E
Santana I
Schröder J
Seo SW
Soininen H
Spiru L
Stomrud E
Struyfs H
Teunissen CE
Verhey FRJ
Vos SJB
van Waalwijk van Doorn LJC
Waldemar G
Wallin ÅK
Wiltfang J
Vandenberghe R
Brooks DJ
Fladby T
Rowe CC
Drzezga A
Verbeek MM
Sarazin M
Wolk DA
Fleisher AS
Klunk WE
Na DL
Sánchez-Juan P
Lee DY
Nordberg A
Tsolaki M
Camus V
Rinne JO
Fagan AM
Zetterberg H
Blennow K
Rabinovici GD
Hansson O
van Berckel BNM
van der Flier WM
Scheltens P
Visser PJ
Ossenkoppele R
Source :
Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2018 Jul; Vol. 14 (7), pp. 913-924. Date of Electronic Publication: 2018 Mar 28.
Publication Year :
2018

Abstract

Introduction: Apolipoprotein E (APOE) ε4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (Aβ) pathology.<br />Methods: We included 3451 Aβ+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE ε4 prevalence in relation to age, sex, education, and geographical location.<br />Results: The APOE ε4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in Aβ+ cognitively normal and Aβ+ mild cognitive impairment (P < .05) but not in Aβ+ AD dementia (P = .66). The prevalence was highest in Northern Europe but did not vary by sex or education.<br />Discussion: The APOE ε4 prevalence in AD was higher than that in previous studies, which did not require presence of Aβ pathology. Furthermore, our results highlight disease heterogeneity related to age and geographical location.<br /> (Copyright © 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1552-5279
Volume :
14
Issue :
7
Database :
MEDLINE
Journal :
Alzheimer's & dementia : the journal of the Alzheimer's Association
Publication Type :
Academic Journal
Accession number :
29601787
Full Text :
https://doi.org/10.1016/j.jalz.2018.02.009