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Differential expression of microRNAs and other small RNAs in muscle tissue of patients with ALS and healthy age-matched controls.
- Source :
-
Scientific reports [Sci Rep] 2018 Apr 04; Vol. 8 (1), pp. 5609. Date of Electronic Publication: 2018 Apr 04. - Publication Year :
- 2018
-
Abstract
- Amyotrophic lateral sclerosis is a late-onset disorder primarily affecting motor neurons and leading to progressive and lethal skeletal muscle atrophy. Small RNAs, including microRNAs (miRNAs), can serve as important regulators of gene expression and can act both globally and in a tissue-/cell-type-specific manner. In muscle, miRNAs called myomiRs govern important processes and are deregulated in various disorders. Several myomiRs have shown promise for therapeutic use in cellular and animal models of ALS; however, the exact miRNA species differentially expressed in muscle tissue of ALS patients remain unknown. Following small RNA-Seq, we compared the expression of small RNAs in muscle tissue of ALS patients and healthy age-matched controls. The identified snoRNAs, mtRNAs and other small RNAs provide possible molecular links between insulin signaling and ALS. Furthermore, the identified miRNAs are predicted to target proteins that are involved in both normal processes and various muscle disorders and indicate muscle tissue is undergoing active reinnervation/compensatory attempts thus providing targets for further research and therapy development in ALS.
- Subjects :
- Adult
Aged
Amyotrophic Lateral Sclerosis genetics
Case-Control Studies
Cluster Analysis
Down-Regulation
Female
High-Throughput Nucleotide Sequencing
Humans
Male
MicroRNAs genetics
Middle Aged
Principal Component Analysis
RNA, Mitochondrial genetics
RNA, Mitochondrial metabolism
RNA, Small Nucleolar genetics
RNA, Small Nucleolar metabolism
RNA, Small Untranslated genetics
Sequence Analysis, RNA
Signal Transduction
Up-Regulation
Amyotrophic Lateral Sclerosis pathology
MicroRNAs metabolism
Muscle, Skeletal metabolism
RNA, Small Untranslated metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 29618798
- Full Text :
- https://doi.org/10.1038/s41598-018-23139-2