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Clinicopathologic and Prognostic Significance of the Zinc Finger of the Cerebellum Family in Invasive Breast Cancer.

Authors :
Han W
Zhang C
Gao XJ
Wang HB
Chen F
Cao F
Hu YW
Ma J
Gu X
Ding HZ
Source :
Journal of breast cancer [J Breast Cancer] 2018 Mar; Vol. 21 (1), pp. 51-61. Date of Electronic Publication: 2018 Mar 23.
Publication Year :
2018

Abstract

Purpose: Five members of the zinc finger of the cerebellum (ZIC) family-ZIC1, ZIC2, ZIC3, ZIC4, and ZIC5-have been shown to be involved in various carcinomas. Here, we aimed to explore the clinicopathologic and prognostic roles of ZIC family members in invasive breast cancer patients using immunohistochemical analysis, western blotting analysis, and real-time quantitative polymerase chain reaction (RT-qPCR).<br />Methods: A total of 241 female invasive breast cancer patients who underwent radical mastectomy between 2009 and 2011 were enrolled. ZIC proteins in 241 pairs of breast tumors and corresponding normal tissues were investigated using immunohistochemistry and the clinicopathologic roles of proteins were analyzed using Pearson's chi-square test. Kaplan-Meier curves and Cox regression analysis were also used to analyze the prognostic value of the ZIC proteins. In addition, 12 pairs of fresh-frozen breast tumors and matched normal tissues were used in the western blotting analysis and RT-qPCR.<br />Results: Only ZIC1 expression in normal tissues was obviously higher than that in tumors ( p <0.001). On multivariate analysis, ZIC1 expression (in overall survival analysis: hazard ratio [HR], 0.405, 95% confidence interval [CI], 0.233-0.702, p =0.001; in disease-free survival analysis: HR, 0.395, 95% CI, 0.234-0.669, p =0.001) was identified as a prognostic indicator of invasive breast cancer.<br />Conclusion: ZIC1, but not the other proteins, was obviously decreased in breast tumors and associated with clinicopathologic factors. Thus, ZIC1 might be a novel indicator to predict the overall and disease-free survival of invasive breast cancer patients.<br />Competing Interests: CONFLICT OF INTEREST: The authors declare that they have no competing interests.

Details

Language :
English
ISSN :
1738-6756
Volume :
21
Issue :
1
Database :
MEDLINE
Journal :
Journal of breast cancer
Publication Type :
Academic Journal
Accession number :
29628984
Full Text :
https://doi.org/10.4048/jbc.2018.21.1.51