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Raspberry anthocyanin consumption prevents diet-induced obesity by alleviating oxidative stress and modulating hepatic lipid metabolism.
- Source :
-
Food & function [Food Funct] 2018 Apr 25; Vol. 9 (4), pp. 2112-2120. - Publication Year :
- 2018
-
Abstract
- Evidence indicates that raspberries have beneficial effects on chronic diseases. The objective of this study was to examine the beneficial effects of raspberry anthocyanin (RA) on high fat diet-induced obesity and investigate the underlying molecular mechanism. C57BL/6 mice were administered a low-fat diet, high-fat diet, and high-fat diet supplemented with RA at a dose of 200 mg kg-1 of food for 12 weeks. It was found that RA reduced the body weight gain by 63.7%. Furthermore, RA significantly elevated serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities and fecal butyric acid level, remarkably reduced the serum and hepatic lipid profiles, and markedly down-regulated the expression of the tumor necrosis factor α (TNFα), interleukin-6 (IL-6), and nuclear factor κB (NF-κB) genes. Metabolomics analysis conducted using gas chromatography time-of-flight mass spectrometry (GC-TOF/MS) indicated that RA administration promoted the recovery of metabolites involved in glycerophospholipid metabolism, insulin signaling pathway, and glutathione metabolism in the livers of obese mice. These findings suggest that RA may ameliorate diet-induced obesity by alleviating oxidative stress and modulating lipid metabolism.
- Subjects :
- Animals
Anthocyanins isolation & purification
Anti-Obesity Agents isolation & purification
Antioxidants isolation & purification
Biomarkers analysis
Biomarkers blood
Biomarkers metabolism
Butyric Acid analysis
Diet, High-Fat adverse effects
Feces chemistry
Female
Fruit chemistry
Gene Expression Regulation
Hyperlipidemias etiology
Hyperlipidemias immunology
Hyperlipidemias metabolism
Hyperlipidemias prevention & control
Hypolipidemic Agents isolation & purification
Hypolipidemic Agents therapeutic use
Lipid Metabolism
Liver immunology
Metabolomics methods
Mice, Inbred C57BL
Obesity etiology
Obesity immunology
Obesity metabolism
Oxidative Stress
Random Allocation
Anthocyanins therapeutic use
Anti-Obesity Agents therapeutic use
Antioxidants therapeutic use
Dietary Supplements
Liver metabolism
Obesity prevention & control
Rubus chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 2042-650X
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Food & function
- Publication Type :
- Academic Journal
- Accession number :
- 29632909
- Full Text :
- https://doi.org/10.1039/c7fo02061a