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Antitumor Research on Artemisinin and Its Bioactive Derivatives.
- Source :
-
Natural products and bioprospecting [Nat Prod Bioprospect] 2018 Aug; Vol. 8 (4), pp. 303-319. Date of Electronic Publication: 2018 Apr 09. - Publication Year :
- 2018
-
Abstract
- Cancer is the leading cause of human death which seriously threatens human life. The antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer properties. Simultaneously, a variety of target-selective artemisinin-related compounds with high efficiency have been discovered. Many researches indicated that artemisinin-related compounds have cytotoxic effects against a variety of cancer cells through pleiotropic effects, including inhibiting the proliferation of tumor cells, promoting apoptosis, inducing cell cycle arrest, disrupting cancer invasion and metastasis, preventing angiogenesis, mediating the tumor-related signaling pathways, and regulating tumor microenvironment. More importantly, artemisinins demonstrated minor side effects to normal cells and manifested the ability to overcome multidrug-resistance which is widely observed in cancer patients. Therefore, we concentrated on the new advances and development of artemisinin and its derivatives as potential antitumor agents in recent 5 years. It is our hope that this review could be helpful for further exploration of novel artemisinin-related antitumor agents.
Details
- Language :
- English
- ISSN :
- 2192-2195
- Volume :
- 8
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Natural products and bioprospecting
- Publication Type :
- Academic Journal
- Accession number :
- 29633188
- Full Text :
- https://doi.org/10.1007/s13659-018-0162-1