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Maternal Serum Interleukin-6: A Non-Invasive Predictor of Histological Chorioamnionitis in Women with Preterm-Prelabor Rupture of Membranes.
- Source :
-
Fetal diagnosis and therapy [Fetal Diagn Ther] 2019; Vol. 45 (3), pp. 168-175. Date of Electronic Publication: 2018 Apr 10. - Publication Year :
- 2019
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Abstract
- Objective: To assess the added value of maternal serum levels of IL-6 in women with preterm-prelabor rupture of membranes (PPROM) as a non-invasive test for the prediction of histological chorioamnionitis (HCA).<br />Methods: This was a prospective cohort study of pregnant women between 20 + 0 and 36 + 6 weeks of gestation with a confirmed diagnosis of PPROM. Logistic regression models were created for the prediction of HCA and compared by assessing the improvement in their Naegelkerke R2 as a measure of goodness of fit. Predictive performance of all models was assessed by receiver operating characteristics curve (ROC) analysis and compared by the DeLong method.<br />Results: From 47 women with PPROM, 31 (66%) developed HCA. Maternal serum IL-6 ≥19.5 pg/dL was the best cut-off point for the prediction of HCA (OR = 15; 95% CI: 3.6-61; p < 0.01). A model comprising maternal characteristics and IL-6 ≥19.5 pg/dL showed an area under the curve of 0.85 (95% CI: 0.74-0.95), significantly improving the previous models of IL-6 ≥19.5 pg/dL (R2: 23.3 vs. 34.1%; p = 0.01) or maternal characteristics (R2: 8.4 vs. 34.1%; p < 0.01).<br />Conclusions: A model comprising maternal serum levels of IL-6 plus maternal characteristics proves to be a good non-invasive predictor of HCA.<br /> (© 2018 S. Karger AG, Basel.)
Details
- Language :
- English
- ISSN :
- 1421-9964
- Volume :
- 45
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Fetal diagnosis and therapy
- Publication Type :
- Academic Journal
- Accession number :
- 29635237
- Full Text :
- https://doi.org/10.1159/000488080