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Key Updates on the Chemistry and Biological Roles of Thiazine Scaffold: A Review.
- Source :
-
Mini reviews in medicinal chemistry [Mini Rev Med Chem] 2018; Vol. 18 (17), pp. 1452-1478. - Publication Year :
- 2018
-
Abstract
- Nitrogen and sulphur based heterocyclic molecules have gained significant attention owing to their broad spectrum pharmacological profiles. Thiazine is one of such promising scaffolds which has been widely utilized in the synthesis of compounds that possess interesting biological profile including anti-proliferative, anti-bacterial, antipsychotic, analgesic, anti-inflammatory, antifungal and antiviral activities. The current review focuses on the chemistry of thiazine and its derivatives along with potential pharmacological activities reported for these in scientific literature. Multifaceted pharmacological profile of thiazine derivatives provides new aspects for the design of superior medicinally active agents.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
- Subjects :
- Analgesics chemical synthesis
Analgesics chemistry
Analgesics pharmacology
Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Anti-Inflammatory Agents, Non-Steroidal chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal chemistry
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Antifungal Agents chemical synthesis
Antifungal Agents chemistry
Antifungal Agents pharmacology
Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Antipsychotic Agents chemical synthesis
Antipsychotic Agents chemistry
Antipsychotic Agents pharmacology
Antiviral Agents chemical synthesis
Antiviral Agents chemistry
Antiviral Agents pharmacology
Humans
Molecular Structure
Thiazines chemical synthesis
Thiazines chemistry
Thiazines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1875-5607
- Volume :
- 18
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Mini reviews in medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 29663882
- Full Text :
- https://doi.org/10.2174/1389557518666180416150552