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Combination of stromal vascular fraction and Ad-COMP-Ang1 gene therapy improves long-term therapeutic efficacy for diabetes-induced erectile dysfunction.
- Source :
-
Asian journal of andrology [Asian J Androl] 2018 Sep-Oct; Vol. 20 (5), pp. 465-472. - Publication Year :
- 2018
-
Abstract
- Men with diabetic erectile dysfunction (ED) respond poorly to the currently available oral phosphodiesterase-5 inhibitors. Therefore, functional therapies for diabetic ED are needed. Stromal vascular fraction (SVF) and the adenovirus-mediated cartilage oligomeric matrix angiopoietin-1 (Ad-COMP-Ang1) gene are known to play critical roles in penile erection. We previously reported that SVF and Ad-COMP-Ang1 have only a short-term effect in restoring erectile function. Further improvements to ED therapy are needed for long-lasting effects. In the present study, we aimed to test if the combination of SVF and Ad-COMP-Ang1 could extend the erection effect in diabetic ED. We found that the combination therapy showed a long-term effect in restoring erectile function through enhanced penile endothelial and neural cell regeneration. Combination therapy with SVF and Ad-COMP-Ang1 notably restored cavernous endothelial cell numbers, pericyte numbers, endothelial cell-cell junctions, decreased cavernous endothelial cell permeability, and promoted neural regeneration for at least 4 weeks in diabetic mice. In summary, this is an initial description of the long-term effect of combination therapy with SVF and Ad-COMP-Ang1 in restoring erectile function through a dual effect on endothelial and neural cell regeneration. Such combination therapy may have therapeutic potential for the treatment of diabetic ED.<br />Competing Interests: All authors declared no competing interests
- Subjects :
- Animals
Diabetes Mellitus, Experimental metabolism
Endothelium, Vascular metabolism
Erectile Dysfunction etiology
Erectile Dysfunction metabolism
Intercellular Junctions metabolism
Male
Mice
Permeability
Angiopoietin-1 genetics
Diabetes Mellitus, Experimental complications
Erectile Dysfunction therapy
Genetic Therapy methods
Mesenchymal Stem Cell Transplantation
Penile Erection physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1745-7262
- Volume :
- 20
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Asian journal of andrology
- Publication Type :
- Academic Journal
- Accession number :
- 29667617
- Full Text :
- https://doi.org/10.4103/aja.aja_16_18