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Characterization of PD-L1 and PD-1 Expression and CD8+ Tumor-infiltrating Lymphocyte in Epstein-Barr Virus-associated Nasopharyngeal Carcinoma.
- Source :
-
American journal of clinical oncology [Am J Clin Oncol] 2018 Dec; Vol. 41 (12), pp. 1204-1210. - Publication Year :
- 2018
-
Abstract
- Objectives: Immunotherapies that target the programmed death-1/ programmed death-1 ligand (PD-1/PD-L1) immune checkpoint pathway have shown promise in nasopharyngeal carcinoma (NPC) in early phases clinical studies. Here, we evaluated PD-1 and PD-L1 expression and CD8+ tumor-infiltrating lymphocytes (TILs) in NPC patients.<br />Materials and Methods: Newly diagnosed NPC patients were identified through the institutional database between January 2007 and December 2012. PD-L1 and PD-1 expression, Epstein-Barr virus (EBV) status, and CD8+ TIL numbers were measured in archival tumor samples at diagnosis and their correlations with clinicopathologic features, including survival, were evaluated.<br />Results: A total of 114 NPC patients were analyzed. Most patients (96%) were EBV positive. PD-L1 was expressed in ≥1% of tumor cells (TCs) in 69% of patients, in ≥50% of TCs in 12% of patients, and in ≥5% of either TCs or infiltrating immune cells in 71% of patients. CD8+ TILs were present in tumors from all patients, whereas only 11% of tumors expressed PD-1. There were no correlations between PD-L1 expression and CD8+ TIL abundance, PD-1 expression, or survival.<br />Conclusions: Approximately 70% of EBV-positive NPC expressed PD-L1, but this did not correlate with patient survival or clinicopathologic features. The findings of this study represent the immune biomarker profile of confirmed EBV-associated NPC in an endemic region. Since the current clinical development of immune checkpoint inhibitor for NPC is mostly focusing on an EBV-associated tumor, differences in immune biomarker profiles and EBV status of endemic and nonendemic regions should be further explored.
- Subjects :
- Aged
Combined Modality Therapy
Epstein-Barr Virus Infections virology
Female
Follow-Up Studies
Herpesvirus 4, Human isolation & purification
Humans
Male
Middle Aged
Nasopharyngeal Carcinoma immunology
Nasopharyngeal Carcinoma metabolism
Nasopharyngeal Carcinoma virology
Prognosis
Prospective Studies
Survival Rate
B7-H1 Antigen metabolism
Biomarkers, Tumor analysis
CD8-Positive T-Lymphocytes immunology
Epstein-Barr Virus Infections complications
Lymphocytes, Tumor-Infiltrating immunology
Nasopharyngeal Carcinoma pathology
Programmed Cell Death 1 Receptor metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1537-453X
- Volume :
- 41
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- American journal of clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 29672367
- Full Text :
- https://doi.org/10.1097/COC.0000000000000449