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Gene polymorphisms of TNF-238G/A, TNF-308G/A, IL10-1082G/A, TNFAIP3, and MC4R and comorbidity occurrence in a Romanian population with psoriasis.
- Source :
-
Journal of medicine and life [J Med Life] 2018 Jan-Mar; Vol. 11 (1), pp. 69-74. - Publication Year :
- 2018
-
Abstract
- Rationale. Psoriasis is a prevalent chronic inflammatory disease with worldwide distribution affecting approximately 2% of the Caucasian population. There have been many population- and family-based studies that agree on the strong genetic component of this disease. Several studies have investigated the relationship between cytokine gene polymorphisms, psoriasis, and the occurrence of comorbidities but their data are conflicting. Objective. This study examines cytokine gene single-nucleotide polymorphisms (SNPs) in the context of psoriasis and metabolic syndrome, with a focus on the occurrence of comorbidities in psoriasis patients. The working hypothesis is that particular SNPs may predispose to an accelerated disease course and more comorbidities in psoriasis patients. Methods: This cross-sectional study was carried out in 2016 in the Dermatology Department of "Elias" University Emergency Hospital, Bucharest and included 82 psoriasis patients. Several clinical and laboratory parameters were recorded, and the presence of metabolic syndrome (MetS) was noted. Using real-time PCR, we tested for the following SNPs: rs361525, rs1800629, rs1800896, rs610604, rs17782313. Results: Disease severity was not significantly influenced by any of the five studied SNPs. Gene polymorphism of rs17782313 was found to influence the occurrence of psoriatic arthritis. In these patients, rs610604 and rs17782313 polymorphisms were associated with the presence of diabetes mellitus. Furthermore, rs17782313 influenced the presence of obesity, heterozygotes being more at risk. Our data suggested that MetS occurred independently of the five studied SNPs. Discussion. The influence of certain cytokine gene polymorphisms on multiple organ systems is justification enough for further analysis of the genetic and molecular mechanisms of metabolic syndrome development in psoriasis patients. Abbreviations: single-nucleotide polymorphisms - SNPs, metabolic syndrome - MetS.
- Subjects :
- Adult
Arthritis, Psoriatic blood
Arthritis, Psoriatic epidemiology
Arthritis, Psoriatic genetics
Comorbidity
Cross-Sectional Studies
Diabetes Mellitus blood
Diabetes Mellitus epidemiology
Diabetes Mellitus genetics
Female
Fibrinogen metabolism
Heterozygote
Humans
Male
Metabolic Syndrome blood
Metabolic Syndrome epidemiology
Metabolic Syndrome genetics
Middle Aged
Obesity blood
Obesity epidemiology
Obesity genetics
Psoriasis blood
Psoriasis epidemiology
Psoriasis pathology
Risk Factors
Romania epidemiology
Severity of Illness Index
White People
Genetic Predisposition to Disease
Interleukin-10 genetics
Polymorphism, Single Nucleotide genetics
Psoriasis genetics
Receptor, Melanocortin, Type 4 genetics
Tumor Necrosis Factor alpha-Induced Protein 3 genetics
Tumor Necrosis Factor-alpha genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1844-3117
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of medicine and life
- Publication Type :
- Academic Journal
- Accession number :
- 29696068