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Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study.
- Source :
-
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society [Liver Transpl] 2018 Sep; Vol. 24 (9), pp. 1221-1232. - Publication Year :
- 2018
-
Abstract
- Little is known about living liver donors' perceptions of their physical well-being following the procedure. We collected data on donor fatigue, pain, and other relevant physical outcomes as part of the prospective, multicenter Adult-to-Adult Living Donor Liver Transplantation Cohort Study consortium. A total of 271 (91%) of 297 eligible donors were interviewed at least once before donation and 3, 6, 12, and 24 months after donation using validated measures when available. Repeated measures regression models were used to identify potential predictors of worse physical outcomes. We found that donors reported more fatigue immediately after surgery that improved by 2 years after donation, but not to predonation levels. A similar pattern was seen across a number of other physical outcomes. Abdominal or back pain and interference from their pain were rated relatively low on average at all study points. However, 21% of donors did report clinically significant pain at some point during postdonation study follow-up. Across multiple outcomes, female donors, donors whose recipients died, donors with longer hospital stays after surgery, and those whose families discouraged donation were at risk for worse physical well-being outcomes. In conclusion, although not readily modifiable, we have identified risk factors that may help identify donors at risk for worse physical outcomes for targeted intervention. Liver Transplantation 00 000-000 2018 AASLD.<br /> (© 2018 by the American Association for the Study of Liver Diseases.)
- Subjects :
- Donor Selection
Fatigue diagnosis
Female
Health Status
Humans
Liver Transplantation methods
Longitudinal Studies
Male
North America
Pain Measurement
Pain, Postoperative diagnosis
Patient Reported Outcome Measures
Prospective Studies
Quality of Life
Recovery of Function
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
Fatigue etiology
Hepatectomy adverse effects
Liver Transplantation adverse effects
Living Donors
Pain, Postoperative etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1527-6473
- Volume :
- 24
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
- Publication Type :
- Academic Journal
- Accession number :
- 29698577
- Full Text :
- https://doi.org/10.1002/lt.25185