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Different biochemical patterns in type II and type III mixed cryoglobulinemia in HCV positive patients.
- Source :
-
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2018 Sep; Vol. 50 (9), pp. 938-943. Date of Electronic Publication: 2018 Apr 04. - Publication Year :
- 2018
-
Abstract
- Background: Reversible cryoprecipitability of proteins is observed as a concomitant feature of immune complex formation. Mixed cryoglobulinemia (MC) is systemic vasculitis, associated with mixed IgM and IgG cryoglobulins (CGs) showing rheumatoid factor (RF) activity. It is frequently associated with hepatitis C virus (HCV). This study investigates the presence of IgG RF and anti-nuclear antibodies (ANA) in cryoprecipitates of patients with type III and type II MC, to understand the biochemical patterns associated with different types of MC to a greater degree.<br />Methods: Sera from 70 HCV untreated patients with type III or type II MC were tested by immunofixation for IgG3 and through ELISA for IgG RF. Cryoprecipitates were analysed for ANA by indirect immunofluorescence to identify specific patterns.<br />Results: After stratification according to MC type, the ANA patterns between type II and type III MC were statistically different. IgG3 levels and IgG-RF positivity were significantly higher in type III cryoprecipitate. We observed a higher positivity of IgG3 and a significant difference between the liver fibrosis stage, ANA and IgG-RF in the cryoprecipitate.<br />Conclusion: Results show a combination of biochemical markers and autoantibodies associated to mixed cryoglobulinemia; these findings could be further investigated in order to ascertain their usefulness in assessing the risk for the development of mixed cryoglobulinemia.<br /> (Copyright © 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Biomarkers blood
Cryoglobulinemia etiology
Cryoglobulins classification
Enzyme-Linked Immunosorbent Assay
Female
Hepatitis C, Chronic blood
Humans
Immunoglobulin G blood
Immunoglobulin M blood
Male
Middle Aged
Retrospective Studies
Antibodies, Antinuclear blood
Cryoglobulinemia blood
Cryoglobulins analysis
Hepatitis C, Chronic complications
Rheumatoid Factor blood
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3562
- Volume :
- 50
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
- Publication Type :
- Academic Journal
- Accession number :
- 29709461
- Full Text :
- https://doi.org/10.1016/j.dld.2018.03.028