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Resting-state fMRI study of brain activation using low-intensity repetitive transcranial magnetic stimulation in rats.
- Source :
-
Scientific reports [Sci Rep] 2018 Apr 30; Vol. 8 (1), pp. 6706. Date of Electronic Publication: 2018 Apr 30. - Publication Year :
- 2018
-
Abstract
- Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique used to treat many neuropsychiatric conditions. However, the mechanisms underlying its mode of action are still unclear. This is the first rodent study using resting-state functional MRI (rs-fMRI) to examine low-intensity (LI) rTMS effects, in an effort to provide a direct means of comparison between rodent and human studies. Using anaesthetised Sprague-Dawley rats, rs-fMRI data were acquired before and after control or LI-rTMS at 1 Hz, 10 Hz, continuous theta burst stimulation (cTBS) or biomimetic high-frequency stimulation (BHFS). Independent component analysis revealed LI-rTMS-induced changes in the resting-state networks (RSN): (i) in the somatosensory cortex, the synchrony of resting activity decreased ipsilaterally following 10 Hz and bilaterally following 1 Hz stimulation and BHFS, and increased ipsilaterally following cTBS; (ii) the motor cortex showed bilateral changes following 1 Hz and 10 Hz stimulation, a contralateral decrease in synchrony following BHFS, and an ipsilateral increase following cTBS; and (iii) hippocampal synchrony decreased ipsilaterally following 10 Hz, and bilaterally following 1 Hz stimulation and BHFS. The present findings demonstrate that LI-rTMS modulates functional links within the rat RSN with frequency-specific outcomes, and the observed changes are similar to those described in humans following rTMS.
- Subjects :
- Animals
Brain Mapping
Evoked Potentials, Motor physiology
Evoked Potentials, Motor radiation effects
Humans
Membrane Potentials radiation effects
Motor Cortex diagnostic imaging
Motor Cortex physiology
Rats
Rats, Sprague-Dawley
Transcranial Magnetic Stimulation adverse effects
Magnetic Resonance Imaging methods
Membrane Potentials physiology
Motor Cortex radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 29712947
- Full Text :
- https://doi.org/10.1038/s41598-018-24951-6