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Colon-specific pulsatile drug release provided by electrospun shellac nanocoating on hydrophilic amorphous composites.
- Source :
-
International journal of nanomedicine [Int J Nanomedicine] 2018 Apr 18; Vol. 13, pp. 2395-2404. Date of Electronic Publication: 2018 Apr 18 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Background: Colon-specific pulsatile drug release, as a combined drug controlled-release model, is a useful drug delivery manner for a series of diseases. New nanomedicines and related preparation methods are highly desired.<br />Methods: With diclofenac sodium (DS) as a model drug, a new type of structural nanocomposite (SC), in which composite polyvinylpyrrolidone (PVP)-DS core was coated by shellac, was fabricated via modified coaxial electrospinning. For comparison, traditional PVP-DS monolithic hydrophilic nanocomposites (HCs) were generated using a traditional blending process. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), attenuated total reflectance-Fourier transform infrared (ATR-FTIR), water contact angle (WCA), and in vitro dissolution and ex vivo permeation tests were conducted to characterize the composites.<br />Results: SEM images demonstrated that both composites were linear nanofibers with smooth surface morphology and cross sections. TEM disclosed that the SCs had a thin shellac sheath layer of approximately 12 nm. XRD and ATR-FTIR results demonstrated that the crystalline DS was converted into amorphous composites with PVP because of favorable secondary interactions. WCA and in vitro dissolution tests demonstrated that the sheath shellac layers in SC could resist acid conditions and provide typical colon-specific pulsatile release, rather than a pulsatile release of HC under acid conditions. Ex vivo permeation results demonstrated that the SCs were able to furnish a tenfold drug permeation rate than the DS particles on the colon membrane.<br />Conclusion: A new SC with a shellac coating on hydrophilic amorphous nanocomposites could furnish a colon-specific pulsatile drug release profile. The modified coaxial process can be exploited as a useful tool to create nanocoatings.<br />Competing Interests: Disclosure The authors report no conflicts of interest in this work.
- Subjects :
- Animals
Delayed-Action Preparations chemistry
Diclofenac administration & dosage
Diclofenac pharmacokinetics
Drug Liberation
Hydrophobic and Hydrophilic Interactions
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Nanofibers chemistry
Povidone chemistry
Resins, Plant chemistry
Spectroscopy, Fourier Transform Infrared
Sus scrofa
X-Ray Diffraction
Colon drug effects
Drug Delivery Systems methods
Nanofibers administration & dosage
Nanotechnology methods
Subjects
Details
- Language :
- English
- ISSN :
- 1178-2013
- Volume :
- 13
- Database :
- MEDLINE
- Journal :
- International journal of nanomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 29713169
- Full Text :
- https://doi.org/10.2147/IJN.S154849