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[The state of lipid peroxidation and enzymes of calcium transport system in sarcoplasmic reticulum of ischemic myocardium].
- Source :
-
Biulleten' eksperimental'noi biologii i meditsiny [Biull Eksp Biol Med] 1988 Sep; Vol. 106 (9), pp. 272-4. - Publication Year :
- 1988
-
Abstract
- In 30 experiments on mongrel dog hearts it was shown that 30 min of total ischemia (37 degrees C) followed by accumulation of MDA in the SR membranes and decrease of their Ca2+-uptake, but had no effect on activity Ca2+-ATPase. After 60-120 min ischemia marked a decrease of Ca2+-uptake and activity Ca2+-ATPase took place, MDA content remained at the increased level. The results show that lipid peroxidation take part in the increase of the permeability of SR membranes for Ca2+ and inhibiting of Ca2+-ATPase.
- Subjects :
- Animals
Biological Transport
Calcium-Transporting ATPases metabolism
Coronary Disease enzymology
Dogs
Intracellular Membranes enzymology
Intracellular Membranes metabolism
Membrane Lipids metabolism
Myocardium enzymology
Phospholipids metabolism
Sarcoplasmic Reticulum enzymology
Calcium metabolism
Coronary Disease metabolism
Lipid Peroxidation
Myocardium metabolism
Sarcoplasmic Reticulum metabolism
Subjects
Details
- Language :
- Russian
- ISSN :
- 0365-9615
- Volume :
- 106
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Biulleten' eksperimental'noi biologii i meditsiny
- Publication Type :
- Academic Journal
- Accession number :
- 2971406