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Lanostane-type C 31 triterpenoid derivatives from the fruiting bodies of cultivated Fomitopsis palustris.
- Source :
-
Phytochemistry [Phytochemistry] 2018 Aug; Vol. 152, pp. 10-21. Date of Electronic Publication: 2018 Apr 30. - Publication Year :
- 2018
-
Abstract
- Fifteen undescribed and five known lanostane-type C <subscript>31</subscript> triterpenoid derivatives were isolated from the aqueous EtOH extract of the fruiting bodies of cultivated Fomitopsis palustris. Their structures were identified from the spectroscopic data and chemical degradation studies. The structures of palustrisoic acids A and H were confirmed by X-ray crystallography. Polyporenic acid B showed strong cytotoxicity against the HCT116, A549, and HepG2 cell lines with IC <subscript>50</subscript> values of 8.4, 12.1, and 12.2 μM, respectively. Palustrisolides A, C, and G displayed weak cytotoxicity.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antineoplastic Agents chemistry
Antineoplastic Agents isolation & purification
Cell Line, Tumor
Cell Proliferation drug effects
Crystallography, X-Ray
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
HCT116 Cells
Hep G2 Cells
Humans
Hydrolysis
Models, Molecular
Molecular Structure
Sodium Hydroxide chemistry
Structure-Activity Relationship
Terpenes chemistry
Terpenes isolation & purification
Antineoplastic Agents pharmacology
Coriolaceae chemistry
Fruiting Bodies, Fungal chemistry
Terpenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3700
- Volume :
- 152
- Database :
- MEDLINE
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 29715599
- Full Text :
- https://doi.org/10.1016/j.phytochem.2018.04.012