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A Single Injection of Human Neutralizing Antibody Protects against Zika Virus Infection and Microcephaly in Developing Mouse Embryos.
- Source :
-
Cell reports [Cell Rep] 2018 May 01; Vol. 23 (5), pp. 1424-1434. - Publication Year :
- 2018
-
Abstract
- Zika virus (ZIKV) is a mosquito-transmitted flavivirus that is generally benign in humans. However, an emergent strain of ZIKV has become widespread, causing severe pre- and post-natal neurological defects. There is now an urgent need for prophylactic and therapeutic agents. To address this, we investigated six human monoclonal antibodies with ZIKV epitope specificity and neutralizing activity in mouse models of ZIKV infection and microcephaly. A single intraperitoneal injection of these antibodies conveyed distinct levels of adult and in utero protection from ZIKV infection, which closely mirrored their respective in vitro neutralizing activities. One antibody, ZK2B10, showed the most potent neutralization activity, completely protected uninfected mice, and markedly reduced tissue pathology in infected mice. Thus, ZK2B10 is a promising candidate for the development of antibody-based interventions and informs the rational design of ZIKV vaccine.<br /> (Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Disease Models, Animal
Embryo, Mammalian pathology
Embryonic Development drug effects
Female
Humans
Mice
Mice, Inbred ICR
Microcephaly metabolism
Microcephaly pathology
Pregnancy
Pregnancy Complications, Infectious metabolism
Pregnancy Complications, Infectious pathology
Zika Virus Infection metabolism
Zika Virus Infection pathology
Antibodies, Monoclonal pharmacology
Antibodies, Neutralizing pharmacology
Antibodies, Viral pharmacology
Embryo, Mammalian embryology
Microcephaly drug therapy
Pregnancy Complications, Infectious drug therapy
Zika Virus metabolism
Zika Virus Infection drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2211-1247
- Volume :
- 23
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cell reports
- Publication Type :
- Academic Journal
- Accession number :
- 29719255
- Full Text :
- https://doi.org/10.1016/j.celrep.2018.04.005