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Vitamin B 2 intake reduces the risk for colorectal cancer: a dose-response analysis.
- Source :
-
European journal of nutrition [Eur J Nutr] 2019 Jun; Vol. 58 (4), pp. 1591-1602. Date of Electronic Publication: 2018 May 09. - Publication Year :
- 2019
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Abstract
- Purpose: Several epidemiological studies have assessed the ability of vitamin B <subscript>2</subscript> to prevent colorectal cancer (CRC), but the results are controversial results. We conducted a dose-response meta-analysis to investigate the association between vitamin B <subscript>2</subscript> and CRC risk.<br />Methods: We searched the PubMed and EMBASE database until January 3, 2018 to identify relevant studies. The pooled relative risks (RRs) with the corresponding 95% confidence intervals (CIs) were calculated using a random-effects model or fixed-effects model. The dose-response relationship was assessed by restricted cubic splines.<br />Results: A total of 14 studies reporting vitamin B <subscript>2</subscript> intake and two studies reporting blood vitamin B <subscript>2</subscript> concentration, comprising 14,934 cases and 1593 cases, respectively, were included in the meta-analysis. Vitamin B <subscript>2</subscript> intake was inversely associated with CRC risk (RR = 0.87; 95% CI 0.81-0.93). Similar results were found for total vitamin B <subscript>2</subscript> intake from diet and supplements (RR = 0.86; 95% CI 0.78-0.94) and dietary vitamin B <subscript>2</subscript> intake (RR = 0.89, 95% CI 0.82-0.98) in subgroup analyses. The dose-response model indicated a non-linear trend, and CRC risk was reduced by 10% when vitamin B <subscript>2</subscript> intake increased to 5 mg/day. In addition, high blood concentrations of vitamin B <subscript>2</subscript> could also reduce the CRC risk (RR = 0.74; 95% CI 0.59-0.92).<br />Conclusions: This dose-response analysis indicates that vitamin B <subscript>2</subscript> intake is inversely associated with CRC risk. The inverse association may also exist between blood vitamin B <subscript>2</subscript> concentration and CRC risk. These results suggest the importance of vitamin B <subscript>2</subscript> intake in the prevention of CRC.
Details
- Language :
- English
- ISSN :
- 1436-6215
- Volume :
- 58
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- European journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 29744609
- Full Text :
- https://doi.org/10.1007/s00394-018-1702-5