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Changes in bone metabolism after gastric cancer surgery in male patients: a prospective observational study.

Authors :
Atsumi Y
Rino Y
Wada H
Kitani Y
Ozawa Y
Aoyama T
Oshima T
Yukawa N
Yoshikawa T
Masuda M
Source :
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association [Gastric Cancer] 2019 Jan; Vol. 22 (1), pp. 237-243. Date of Electronic Publication: 2018 May 10.
Publication Year :
2019

Abstract

Background: Several retrospective studies have shown that bone disorders occur after gastric cancer surgery. This study was designed to prospectively evaluate the changes in bone metabolism after gastrectomy for gastric cancer.<br />Methods: We prospectively enrolled 39 men with early gastric cancer who underwent gastrectomy. We excluded women to avoid the effects of menopause. We employed dual energy X-ray absorptiometry (DEXA) to measure bone mineral density (BMD) of the lumbar spine. DEXA was performed before and 1 and 2 years after surgery. The serum levels of alkaline phosphatase (ALP), 1,25-dihydroxy vitamin D [1,25(OH) <subscript>2</subscript> VD], 25-hydroxy vitamin D [25(OH)VD], and estradiol were measured before surgery and every 3 months until 2 years after surgery.<br />Results: DEXA revealed that BMD significantly decreased by 0.036 ± 0.033 g/cm <superscript>2</superscript> 12 months after gastrectomy (P < 0.001) and by 0.046 ± 0.040 g/cm <superscript>2</superscript> 24 months after gastrectomy (P < 0.001). The serum ALP level significantly increased by 38.31 ± 103.8 IU/L 24 months after surgery (P = 0.013). The serum 25(OH)VD level significantly decreased by 4.88 ± 6.42 ng/ml 24 months after surgery (P < 0.001), whereas the serum 1,25(OH) <subscript>2</subscript> VD levels were consistently in the normal range. The serum estradiol level significantly increased by 2.94 ± 7.49 pg/ml 12 months after gastrectomy (P = 0.035). A lower preoperative body mass index (BMI) significantly correlated with the reduction in BMD 12 months after surgery; the correlation coefficient was 0.37 (P = 0.025).<br />Conclusions: This study showed that a significant decrease in BMD was observed for up to 24 months after gastrectomy, not only 12 months.

Details

Language :
English
ISSN :
1436-3305
Volume :
22
Issue :
1
Database :
MEDLINE
Journal :
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Publication Type :
Academic Journal
Accession number :
29748875
Full Text :
https://doi.org/10.1007/s10120-018-0835-9