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2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain.
- Source :
-
Progress in lipid research [Prog Lipid Res] 2018 Jul; Vol. 71, pp. 1-17. Date of Electronic Publication: 2018 May 08. - Publication Year :
- 2018
-
Abstract
- 2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the cannabinoid CB <subscript>1</subscript> receptor. It is involved in a wide array of (patho)physiological functions, such as emotion, cognition, energy balance, pain sensation and neuroinflammation. In this review, we describe the biosynthetic and metabolic pathways of 2-AG and how chemical and genetic perturbation of these pathways has led to insight in the biological role of this signaling lipid. Finally, we discuss the potential therapeutic benefits of modulating 2-AG levels in the brain.<br /> (Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Animals
Arachidonic Acids chemical synthesis
Arachidonic Acids chemistry
Biosynthetic Pathways
Endocannabinoids chemical synthesis
Endocannabinoids chemistry
Glycerides chemical synthesis
Glycerides chemistry
Humans
Models, Chemical
Molecular Structure
Receptor, Cannabinoid, CB1 metabolism
Arachidonic Acids metabolism
Brain metabolism
Endocannabinoids metabolism
Glycerides metabolism
Lipid Metabolism
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2194
- Volume :
- 71
- Database :
- MEDLINE
- Journal :
- Progress in lipid research
- Publication Type :
- Academic Journal
- Accession number :
- 29751000
- Full Text :
- https://doi.org/10.1016/j.plipres.2018.05.002