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Preparation of micrometric powders of parathyroid hormone (PTH1-34)-loaded chitosan oligosaccharide by supercritical fluid assisted atomization.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 2018 Jul 10; Vol. 545 (1-2), pp. 389-394. Date of Electronic Publication: 2018 May 08. - Publication Year :
- 2018
-
Abstract
- Parathyroid hormone (PTH1-34)-loaded dry powders were fabricated from aqueous solution for pulmonary administration using supercritical fluid assisted atomization introduced by a hydrodynamic cavitation mixer (SAA-HCM). Herein, chitosan oligosaccharide (CSO) was selected as a carrier in an effort to enhance transmucosal absorption of the drug. Well-defined, separated and spherical PTH(1-34)/CSO composite microparticles were obtained, and the particles size could be well controlled with narrow distribution. Aerodynamic performance was determined using next generation impactor (NGI), and the mass median aerodynamic diameter (MMAD) ranged strictly 1-5 μm range with fine particle fraction (FPF) up to 63.51%. The structural integrity of coprecipitated PTH(1-34) was validated by HPLC, FT-IR and circular dichroism, and a high loading efficiency up to 92.8% was obtained. TGA analyses revealed its thermal stability was preserved and XRD patterns showed amorphous structure of particles. The SAA-HCM process is proposed as a green technique for preparation of inhalable protein/polymer composite dry powders without use of any organic solvents.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Administration, Inhalation
Aerosols
Chromatography, High Pressure Liquid
Circular Dichroism
Crystallography, X-Ray
Drug Compounding
Drug Stability
Dry Powder Inhalers
Parathyroid Hormone chemistry
Particle Size
Powders
Spectroscopy, Fourier Transform Infrared
Thermogravimetry
Chitosan chemistry
Drug Carriers
Oligosaccharides chemistry
Parathyroid Hormone administration & dosage
Technology, Pharmaceutical methods
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3476
- Volume :
- 545
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 29751142
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2018.05.022