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Tumour volume of resectable oesophageal squamous cell carcinoma measured with MRI correlates well with T category and lymphatic metastasis.
- Source :
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European radiology [Eur Radiol] 2018 Nov; Vol. 28 (11), pp. 4757-4765. Date of Electronic Publication: 2018 May 14. - Publication Year :
- 2018
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Abstract
- Objectives: To determine association of gross tumour volume (GTV) of resectable oesophageal squamous cell carcinoma (SCC) measured on T <subscript>2</subscript> -weighted imaging (T <subscript>2</subscript> WI), contrast-enhanced T <subscript>1</subscript> -weighted imaging (CE-T <subscript>1</subscript> WI) and diffusion-weighted imaging (DWI) with T category and lymphatic metastasis (LM).<br />Methods: Sixty oesophageal SCC patients underwent fat-suppressed T <subscript>2</subscript> WI, CE-T <subscript>1</subscript> WI and DWI with b values of 0, 500 and 800 s/mm <superscript>2</superscript> . GTV was measured on three sequences. Statistical analyses were performed to determine association of GTV with T category and LM.<br />Results: Spearman's rank correlation analysis showed positive association of GTV with T category and LM (all p values < 0.01). Differences in GTV were found between T1 and T2 or T3 categories shown by Kruskal-Wallis H and one-way ANOVA tests, and between T1/T2 and T3 and between tumours with and without LM by Mann-Whitney U tests (all p values < 0.05). Receiver operating characteristic analyses showed cut-off GTVs of 5.795, 5.276 and 10.11 cm <superscript>3</superscript> on CE-T <subscript>1</subscript> WI could better differentiate T1 from T2 categories, T1 from T3, and T1-2 from T3 than those of 7.066, 7.045 and 8.504 cm <superscript>3</superscript> on T <subscript>2</subscript> WI, of 5.793, 6.609 and 6.989 cm <superscript>3</superscript> on DWI with b value of 500 s/mm <superscript>2</superscript> , and of 4.156, 4.519 and 4.985 cm <superscript>3</superscript> with b value of 800 s/mm <superscript>2</superscript> , respectively. Cut-off of 10.462 cm <superscript>3</superscript> on DWI with b value of 500 s/mm <superscript>2</superscript> could better identify LM than of 12.38, 8.793 and 9.600 cm <superscript>3</superscript> on T <subscript>2</subscript> WI, CE-T <subscript>1</subscript> WI and DWI with b value of 800 s/mm <superscript>2</superscript> , respectively.<br />Conclusions: GTVs on T <subscript>2</subscript> WI, CE-T <subscript>1</subscript> WI and DWI are associated with T category of and LM of oesophageal SCC.<br />Key Points: • GTV is associated with T category and lymphatic metastasis of oesophageal SCC • GTV measured on contrast-enhanced T <subscript>1</subscript> -weighted imaging better identifies T category • GTV measured on DWI with b value of 500 s/mm <superscript>2</superscript> better identifies lymphatic metastasis.
- Subjects :
- Aged
Analysis of Variance
Diffusion Magnetic Resonance Imaging
Esophageal Squamous Cell Carcinoma diagnostic imaging
Female
Humans
Male
Middle Aged
ROC Curve
Tumor Burden
Esophageal Squamous Cell Carcinoma pathology
Lymphatic Metastasis pathology
Magnetic Resonance Imaging methods
Neoplasm Staging methods
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1084
- Volume :
- 28
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- European radiology
- Publication Type :
- Academic Journal
- Accession number :
- 29761360
- Full Text :
- https://doi.org/10.1007/s00330-018-5477-0